[Low grade fibromixoid sarcoma: a purpose of 3 cases and review of the bibliography].

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April 28, 2021 0 Comments

[Low grade fibromixoid sarcoma: a purpose of 3 cases and review of the bibliography].

BACKGROUND
Low grade fibromyxoid sarcoma or tumor Evans is a variety of soft tissue sarcoma that represents 1% of all malignancies. More common in limbs and trunk (50%), we present 3 new cases of retroperitoneal reviewing their characteristics and performing a literature review.
METHODS
In the retroperitoneal location highlights the poor specificity of clinical symptoms, demonstrating, according to their growth and size, as an abdominal tumor, usually painless, or by compression and/or invasion of nearby structures. In cases that present the most important finding was the presence of a palpable abdominal tumor without other symptoms despite remarkable infiltration of other organs that should be included in surgical resection.
CONCLUSIONS
We emphasize the difficulty of correct diagnosis preoperatively because preoperative studies are inconclusive and only the histological and immunohisto-typing chemistry allow precise identification.
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[Determination of ER-D5 (estrogen receptor related antigen) in prostatic cancer and its significance].

The existence of an estrogen receptor and various other sex steroid receptors has been confirmed in prostatic cancer. However, the action mechanism of hormone therapy and relationship between the disappearance of hormone response, which is observed in the recurrence of prostatic cancer, and various sex steroid receptors have yet to be identified. The use of monoclonal antibody ERICA is known as a method of detecting the estrogen receptor in the immunohistological chemistry method. However, this monoclonal antibody is difficult to use on paraffin sections. Therefore, using monoclonal antibody D5, which allows ER-D5 detection of the estrogen receptor related antigen on paraffin sections, we investigated whether or not estrogen receptors are present in the prostatic cancer preparation and studied the survival rate of prostatic cancer as well as relationship with recurrence.
Positive ER-D5 results were obtained in 37 of 93 prostatic cancer cases (39.8%) and in all 20 prostatic hypertrophy cases (100%). ER-D5 tended to be more densely stained in prostatic hypertrophy than in prostatic cancer. The survival rate was obviously higher in the ER-D5 positive prostatic cancer cases than in ER-D5 negative cases for a certain period of time after the start of treatment. Despite differences in the histo-differentiation degree and clinical stage of prostatic cancer, the ER-D5 positive percentage did not change and remained between 35% and 45%. In cases where another prostatic cancer preparation was taken because of recurrence of prostatic cancer, there were no ER-D5 positive cases at the time of recurrence.(ABSTRACT TRUNCATED AT 250 WORDS)

Activation of TRPV4 channels leads to a consistent tocolytic effect on human myometrial tissues

Background: Human myometrium is a therapeutic target for labor induction and preterm labor.
Objective: This study aimed to assess the physiological role of alternative calcium conductance on contractions triggered by uterotonic drugs in human myometrium. Membrane conductances, supported by TRPV channels, may provide alternative pathways to control either free intracellular and/or submembrane Ca2+-concentration, which in turn will modulate membrane polarization and contractile responses.
Study design: Uterine biopsies were obtained from consenting women undergoing elective caesarean delivery at term without labor (N = 22). Isometric tension measurements were performed on uterine smooth muscle strips (n = 132). Amplitude, frequency, and area under the curve (AUC) of phasic contractions, as well as resting tone, were measured under various experimental conditions. Immuno histo– and cyto-chemistry, as well as Western blot analyses, have been performed with specific antibodies against TRPV1, TRPV3, and TRPV4 proteins. TRPV4 agonists; GSK1016790A, 4αPDD, and 5,6-EET were used to assess the role of TRPV4 channels on rhythmic activity triggered by 30-300 nM oxytocin. 5 μM of ruthenium red was used as an efficient blocker of ionic current through TRPV4 channels. Nanomolar concentrations of iberiotoxin (IbTX) were also used to confirm the downstream involvement of BKCa channels in controlling uterine reactivity and contractility.
Results: The expression of TRPV3 and TRPV4 isoforms has now been demonstrated in human myometrial tissue and cell culture. Nanomolar concentrations of the TRPV4 agonists, (either GSK1016790A or 4αPDD) abolished the rhythmic contractions, resulting in a rapid and consistent tocolytic effect. While 5 μM of ruthenium reversed this tocolytic effect. The addition of IbTX (a BKCa channel blocker) reversed the effects of GSK1016790A. Carvacrol, a TRPV3 agonist, had similar tocolytic effects on rhythmic contractions albeit at higher concentrations. This inhibitory effect was also reversed by ruthenium red.
Conclusion: Collectively, these data suggest that activation of TRPV4 leads to a Ca2+ entry and subsequent BKCa channel activation (increase in open state probability), which in turn hyperpolarizes the myometrial cell membrane, inactivating L-type Ca2+ channels and efficiently abrogates contractile activity. Consequently, alternative Ca2+ conductance supported by TRPV4 plays a physiological role in the modulation of myometrial reactivity.

The real-time polymerase chain reaction.

The scientific, medical, and diagnostic communities have been presented the most powerful tool for quantitative nucleic acids analysis: real-time PCR [Bustin, S.A., 2004. A-Z of Quantitative PCR. IUL Press, San Diego, CA]. This new technique is a refinement of the original Polymerase Chain Reaction (PCR) developed by Kary Mullis and coworkers in the mid 80:ies [Saiki, R.K., et al., 1985. Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia, Science 230, 1350], for which Kary Mullis was awarded the 1993 year’s Nobel prize in Chemistry.

Recombinant Mouse GM-CSF/CSF2

CK02-10ug 10ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH7.4.

Recombinant Mouse GM-CSF/CSF2

CK02-1mg 1mg
EUR 2983.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH7.4.

Recombinant Mouse GM-CSF/CSF2

CK02-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH7.4.

Recombinant Mouse GM-CSF/CSF2

CK02-50ug 50ug
EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH7.4.

Recombinant Human GM-CSF (CSF2)

Z100275 20 µg
EUR 85
Description: GM-CSF is a hematopoietic growth factor that is produced by endothelial cells, monocytes, fibroblasts and T-lymphocytes following their activation by antigens or mitogens. GM-CSF stimulates the development of macrophages and neutrophils and plays a role in the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. Approximately 90% of the secreted colony stimulating activities are due to GM-CSF. While non-glycosylated and glycosylated GM-CSF show similar activities in vitro, fully glycosylated GM-CSF is biologically more active in vivo compared to its non-glycosylated counterpart. Human and murine GM-CSF are species-specific and therefore, exhibit no cross-reactivity. Recombinant Human GM-CSF is a non-glycosylated, monomeric protein that contains intra-chain disulfide bonds.

Recombinant Human GM-CSF (CSF2)

Z100277 100 µg
EUR 210
Description: GM-CSF is a hematopoietic growth factor that is produced by endothelial cells, monocytes, fibroblasts and T-lymphocytes following their activation by antigens or mitogens. GM-CSF stimulates the development of macrophages and neutrophils and plays a role in the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. Approximately 90% of the secreted colony stimulating activities are due to GM-CSF. While non-glycosylated and glycosylated GM-CSF show similar activities in vitro, fully glycosylated GM-CSF is biologically more active in vivo compared to its non-glycosylated counterpart. Human and murine GM-CSF are species-specific and therefore, exhibit no cross-reactivity. Recombinant Human GM-CSF is a non-glycosylated, monomeric protein that contains intra-chain disulfide bonds.

Recombinant Human GM-CSF (CSF2)

Z100279 10 x 100 µg (Z100277 x 10)
EUR 1980
Description: GM-CSF is a monomeric protein of 127 amino acids with two glycosylation sites. The protein is synthesized as a precursor of 144 amino acids, which included a hydrophobic secretory signal sequence at the amino terminal end. The sugar moiety is not required for the full spectrum of biological activities. Non-glycosylated and glycosylated GM-CSF show the same activities in vitro. Fully glycosylated GM-CSF is biologically more active in vivo than the non-glycosylated protein. This protein is secreted together with other factors by T cells and macrophages following cell activation by antigens or mitogens. Approximately 90% of the secreted colony stimulating activities are due to GM-CSF.

Recombinant Mouse GM-CSF (CSF2)

Z200075 20 µg
EUR 190
Description: GM-CSF is a monomeric cytokine with two glycosylation sites that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. CSF2 is secreted together with other factors by T cells and macrophages following cell activation by antigens or mitogens. The signalling ‘GM-CSF:receptor’ complex is a dodecamer of two hexamers of two alpha, two beta, and two ligand subunits. While non-glycosylated and glycosylated GM-CSF show similar activities in vitro, fully glycosylated GM-CSF is biologically more active in vivo. Recombinant Mouse CSF2 is a non-glycosylated, monomeric protein.

Recombinant Mouse GM-CSF (CSF2)

Z200077 5 x 20 µg (Z200075 x 5)
EUR 850
Description: GM-CSF is a monomeric cytokine with two glycosylation sites that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes. CSF2 is secreted together with other factors by T cells and macrophages following cell activation by antigens or mitogens. The signalling ‘GM-CSF:receptor’ complex is a dodecamer of two hexamers of two alpha, two beta, and two ligand subunits. While non-glycosylated and glycosylated GM-CSF show similar activities in vitro, fully glycosylated GM-CSF is biologically more active in vivo. Recombinant Mouse CSF2 is a non-glycosylated, monomeric protein.

Recombinant Mouse GM-CSF (CSF2)

Z200079 1.0 mg
EUR 4350
Description: GM-CSF is a monomeric protein of 127 amino acids with two glycosylation sites. The protein is synthesized as a precursor of 144 amino acids, which included a hydrophobic secretory signal sequence at the aminoterminal end. The sugar moiety is not required for the full spectrum of biological activities. Non-glycosylated and glycosylated GM-CSF show the same activities in vitro. Fully glycosylated GM-CSF is biologically more active in vivo than the non- glycosylated protein. This protein is secreted together with other factors by T cells and macrophages following cell activation by antigens or mitogens. Approximately 90% of the secreted colony stimulating activities are due to GM-CSF.

Recombinant Rat GM-CSF/CSF2 Protein

RP01207 5 μg
EUR 174

Recombinant Human GM-CSF/CSF2 Protein

RP00094 5 μg
EUR 178.8

Recombinant Mouse GM-CSF/CSF2 Protein

RP01206 5 μg
EUR 174

GM-CSF, rat recombinant

4102-10 each
EUR 307.2

GM-CSF, rat recombinant

4102-100 each
EUR 966

GM-CSF, rat recombinant

4102-1000 each
EUR 4561.2

GM-CSF, rat recombinant

P1014-.1 100 µg
EUR 1220.4
Description: Granulocyte Macrophage Colony stimulating Factor (GM-CSF) is a cytokine that stimulates the colony formation of granulocyte-macrophage progenitors. GM-CSF is a pleiotropic cytokine and a member of endogenous cytokine family of the hematopoietic system.

GM-CSF, rat recombinant

P1014-1 1 mg
EUR 5822.4
Description: Granulocyte Macrophage Colony stimulating Factor (GM-CSF) is a cytokine that stimulates the colony formation of granulocyte-macrophage progenitors. GM-CSF is a pleiotropic cytokine and a member of endogenous cytokine family of the hematopoietic system.

Recombinant Rat GM-CSF

REOPP-0701 5ug Ask for price

Recombinant Human GM-CSF/CSF2 (E. coli)

C003-10ug 10ug
EUR 201.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Mannitol, pH 7.2.

Recombinant Human GM-CSF/CSF2 (E. coli)

C003-1mg 1mg
EUR 2203.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Mannitol, pH 7.2.

Recombinant Human GM-CSF/CSF2 (E. coli)

C003-500ug 500ug
EUR 1557.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Mannitol, pH 7.2.

Recombinant Human GM-CSF/CSF2 (E. coli)

C003-50ug 50ug
EUR 486
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB, 150mM NaCl, 5% Mannitol, pH 7.2.

Recombinant Mouse GM-CSF/CSF2 (C-6His)

CJ46-10ug 10ug
EUR 242.4
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH7.4.

Recombinant Mouse GM-CSF/CSF2 (C-6His)

CJ46-1mg 1mg
EUR 2983.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH7.4.

Recombinant Mouse GM-CSF/CSF2 (C-6His)

CJ46-500ug 500ug
EUR 1935.6
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH7.4.

Recombinant Mouse GM-CSF/CSF2 (C-6His)

CJ46-50ug 50ug
EUR 595.2
Description: Lyophilized from a 0.2 μm filtered solution of 20mM PB,150mM NaCl, pH7.4.

GM-CSF, human recombinant

4100-10 each
EUR 307.2

GM-CSF, human recombinant

4100-100 each
EUR 874.8

GM-CSF, human recombinant

4100-1000 each
EUR 3974.4

GM-CSF, human recombinant

P1012-.01 10 µg
EUR 375.6
Description: Granulocyte Macrophage Colony stimulating Factor (GM-CSF) is a cytokine that stimulates the colony formation of granulocyte-macrophage progenitors. GM-CSF is a pleiotropic cytokine and a member of endogenous cytokine family of the hematopoietic system

GM-CSF, human recombinant

P1012-.1 100 µg
EUR 1220.4
Description: Granulocyte Macrophage Colony stimulating Factor (GM-CSF) is a cytokine that stimulates the colony formation of granulocyte-macrophage progenitors. GM-CSF is a pleiotropic cytokine and a member of endogenous cytokine family of the hematopoietic system

GM-CSF, human recombinant

P1012-1 1 mg
EUR 5071.2
Description: Granulocyte Macrophage Colony stimulating Factor (GM-CSF) is a cytokine that stimulates the colony formation of granulocyte-macrophage progenitors. GM-CSF is a pleiotropic cytokine and a member of endogenous cytokine family of the hematopoietic system

Recombinant Human GM-CSF

SJA01-03 10µg/vial
EUR 342

Recombinant Human GM-CSF

SJA01-04 50µg/vial
EUR 846

Recombinant Mouse GM-CSF

SJF05-01 10µg/vial
EUR 307.2

Recombinant Mouse GM-CSF

SJF05-02 50µg/vial
EUR 690

Recombinant Mouse GM-CSF

6511 5 µg
EUR 194

Recombinant Human GM-CSF

6585 5 µg
EUR 194

Recombinant Human GM-CSF

EPT108 500ug
EUR 1553.4
Description: Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor is produced by our Yeast expression system and the target gene encoding Ala18-Glu144 is expressed.

Recombinant Mouse GM-CSF

EPT161 50ug
EUR 491.4
Description: Recombinant Mouse Granulocyte-Macrophage Colony-Stimulating Factor is produced by our E.coli expression system and the target gene encoding Ala18-Lys141 is expressed.

Recombinant Human GM-CSF

HEOPP-0704 5ug Ask for price

Mouse GM-CSF Recombinant

IMSGMCSFR25UG each
EUR 482
Description: Mouse GM-CSF Recombinant

Mouse GM-CSF Recombinant

IMSGMCSFR5UG each
EUR 283
Description: Mouse GM-CSF Recombinant

GM-CSF, murine recombinant

4101-10 each
EUR 307.2

GM-CSF, murine recombinant

4101-100 each
EUR 874.8

GM-CSF, murine recombinant

4101-1000 each
EUR 3974.4

GM-CSF, murine recombinant

P1013-.01 10 µg
EUR 375.6
Description: Granulocyte Macrophage Colony stimulating Factor (GM-CSF) is a cytokine that stimulates the colony formation of granulocyte-macrophage progenitors. GM-CSF is a pleiotropic cytokine and a member of endogenous cytokine family of the hematopoietic system.

GM-CSF, murine recombinant

P1013-.1 100 µg
EUR 1220.4
Description: Granulocyte Macrophage Colony stimulating Factor (GM-CSF) is a cytokine that stimulates the colony formation of granulocyte-macrophage progenitors. GM-CSF is a pleiotropic cytokine and a member of endogenous cytokine family of the hematopoietic system.

GM-CSF, murine recombinant

P1013-1 1 mg
EUR 5071.2
Description: Granulocyte Macrophage Colony stimulating Factor (GM-CSF) is a cytokine that stimulates the colony formation of granulocyte-macrophage progenitors. GM-CSF is a pleiotropic cytokine and a member of endogenous cytokine family of the hematopoietic system.

Recombinant Canine GM-CSF

CEOPP-0701 5ug Ask for price

Recombinant Murine GM-CSF

MEOPP-0702 5ug Ask for price

GM-CSF Recombinant Protein

40-281-0005mg 0.005 mg
EUR 311.1
Description: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites.

GM-CSF Recombinant Protein

40-281-002mg 0.02 mg
EUR 437.1
Description: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites.

GM-CSF Recombinant Protein

40-448-0005mg 0.005 mg
EUR 311.1
Description: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant murine GM-CSF is a 14.2 kDa globular protein consisting of 124 amino acids residues.

GM-CSF Recombinant Protein

40-448-002mg 0.02 mg
EUR 437.1
Description: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant murine GM-CSF is a 14.2 kDa globular protein consisting of 124 amino acids residues.

GM-CSF Recombinant Protein

40-475-0005mg 0.005 mg
EUR 311.1
Description: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant rat GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acids residues.

GM-CSF Recombinant Protein

40-475-002mg 0.02 mg
EUR 437.1
Description: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant rat GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acids residues.

GM-CSF Recombinant Protein

40-593 0.02 mg
EUR 481.2
Description: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites.

GM-CSF Recombinant Protein

40-617 0.02 mg
EUR 481.2
Description: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant murine GM-CSF is a 14.2 kDa globular protein consisting of 124 amino acids residues. .

GM-CSF Recombinant Protein

40-621 0.02 mg
EUR 481.2
Description: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant murine GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acids residues.

GM-CSF Recombinant Protein

91-002 0.05 mg
EUR 714.3
Description: Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic, monocytes/ macrophages and eosinophils. GM-CSF has a functional role on non-hematopoitic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines.

GM-CSF Recombinant Protein

91-030 0.05 mg
EUR 651.3
Description: GM-CSF was initially characterized as a growth factor that can support the in vitro colony formation of granulocyte macrophage progenitors. It is produced by a number of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cells and fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophage progenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. On mature hematopoietic, monocytes/macrophages, and eosinophils, GM-CSF has also been reported to have a functional role on non-hematopoitic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF can also stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma and adenocarcinoma cell lines.

GM-CSF Recombinant Protein

91-857 0.05 mg
EUR 619.8
Description: Granulocyte-macrophage colony-stimulating factor is also known as Colony-stimulating factor,CSF, Molgramostin and Sargramostim. In humans, it is encoded by the CSF2 gene. It belongs to the GM-CSF family. Granulocyte-macrophage colony-stimulating factor is a cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes.

GM-CSF Recombinant Protein

92-446 0.05 mg
EUR 821.4
Description: Granulocyte-Macrophage Colony Stimulating Factor (GM-CSF) was initially characterized as a growth factorthat can support the in vitro colony formation of granulocyte-macrophage progenitors. It is produced by anumber of different cell types (including activated T cells, B cells, macrophages, mast cells, endothelial cellsand fibroblasts) in response to cytokine of immune and inflammatory stimuli. Besides granulocyte-macrophageprogenitors, GM-CSF is also a growth factor for erythroid, megakaryocyte and eosinophil progenitors. Onmature hematopoietic, monocytes/ macrophages and eosinophils. GM-CSF has a functional role on nonhematopoitic cells. It can induce human endothelial cells to migrate and proliferate. Additionally, GM-CSF canalso stimulate the proliferation of a number of tumor cell lines, including osteogenic sarcoma, carcinoma andadenocarcinoma cell lines.

GM-CSF Recombinant Protein

92-499 0.05 mg
EUR 821.4
Description: Granulocyte-macrophage colony-stimulating factor is an enzyme that in mouse is encoded by the Csf2 gene, belongs to the GM-CSF family.CSF2 is a Cytokine that stimulates the growth and differentiation of hematopoietic precursor cells from various lineages, including granulocytes, macrophages, eosinophils and erythrocytes

GM-CSF Recombinant Protein

90-553 50 ug
EUR 588.3
Description: Human GM-CSF is a 24 kDa glycoprotein produced by a variety of cell types, including T and B lymphocytes, macrophages, keratinocytes, eosinophils, neutrophils, and endothelial cells in response to cytokine or inflammatory stimuli. GM-CSF was initially identified on the basis of its capacity to stimulate the clonal proliferation of myeloid precursors in vitro. GM-CSF promotes a Th1 biased immune response, allergic inflammation, and the development of autoimmunity. GM-CSF are particularly effective as antitumor vaccines. GM-CSF regulates multiple biological activities through activation of the GM-CSF receptor (GMCSFR), a member of the type I cytokine receptor group comprising alpha and beta subunits.

GM-CSF, Porcine Recombinant

P1561-10 10 µg
EUR 187.2

GM-CSF, Porcine Recombinant

P1561-50 50 µg
EUR 661.2

Recombinant Human GM-CSF/CSF2 (P. pastoris)

C040-10ug 10ug
EUR 187.2
Description: Lyophilized from a 0.2 μm filtered solution of 10mM TrisHCl, 4% Mannitol, 1% Sucrose, pH 8.5.

Recombinant Human GM-CSF/CSF2 (P. pastoris)

C040-1mg 1mg
EUR 2496
Description: Lyophilized from a 0.2 μm filtered solution of 10mM TrisHCl, 4% Mannitol, 1% Sucrose, pH 8.5.

Recombinant Human GM-CSF/CSF2 (P. pastoris)

C040-500ug 500ug
EUR 1765.2
Description: Lyophilized from a 0.2 μm filtered solution of 10mM TrisHCl, 4% Mannitol, 1% Sucrose, pH 8.5.

Recombinant Human GM-CSF/CSF2 (P. pastoris)

C040-50ug 50ug
EUR 442.8
Description: Lyophilized from a 0.2 μm filtered solution of 10mM TrisHCl, 4% Mannitol, 1% Sucrose, pH 8.5.

Recombinant Rat GM-CSF/CSF2 Protein, His Tag

E40KMP1331 20ug
EUR 495

Recombinant Mouse GM-CSF/Csf2 Protein, No Tag

E40MOP2170 20ug
EUR 495

Recombinant Human GM-CSF/CSF2 Protein, No Tag

E40KMH1174 20ug
EUR 495

Recombinant Human GM-CSF/CSF2 Protein, No Tag

E40KMH1176 20ug
EUR 495

GM CSF Recombinant Protein Tag free Lyophilized

IGMCSFRLY20UG each
EUR 568
Description: GM CSF Recombinant Protein Tag free Lyophilized

Recombinant Mouse GM-CSF/Csf2 Protein, His Tag

E40MOP2169 20ug
EUR 495

Recombinant Human GM-CSF/CSF2 Protein, His Tag

E40KMP1102 20ug
EUR 495

Recombinant Mouse GM-CSF/CSF2 Protein, His Tag

E40KMP1339 20ug
EUR 495

Recombinant Human GM-CSF/CSF2 Protein, His Tag

E40KMH1175 20ug
EUR 495

Recombinant Bovine Uter

P0136 100ug
EUR 626.83
Description: Recombinant Bovine protein for Uter

Recombinant Bovine IFNG

P0146 100ug
EUR 626.83
Description: Recombinant Bovine protein for IFNG

Recombinant Bovine TNFA

P0153 100ug
EUR 626.83
Description: Recombinant Bovine protein for TNFA

Recombinant Bovine CST3

P0184 100ug
EUR 626.83
Description: Recombinant Bovine protein for CST3

Recombinant Bovine bFGF

BEGFP-0601 10ug Ask for price

Recombinant Human GM-CSF R alpha/CSF2RA Protein

RP00563 10 μg
EUR 208.8

Recombinant bovine TNNT3

P1041 100ug Ask for price
Description: Recombinant protein for bovine TNNT3

Recombinant Rat GM-CSF Protein

PROTP48750-1 20ug
EUR 380.4
Description: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in by endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant rat GM-CSF is a 14.5 kDa globular protein consisting of 128 amino acids residues.

Recombinant Bovine Leptin

7-01162 20µg Ask for price

Recombinant Bovine Leptin

7-01163 100µg Ask for price

Recombinant Bovine Leptin

7-01164 1mg Ask for price

Recombinant Bovine Leptin

P0187 100ug
EUR 626.83
Description: Recombinant Bovine protein for Leptin

Recombinant Bovine Rantes

P0440 100ug
EUR 626.83
Description: Recombinant Bovine protein for Rantes

Recombinant Bovine Trypsin

7-06739 1mg Ask for price

Recombinant Bovine Trypsin

7-06740 5mg Ask for price

Recombinant Bovine Trypsin

7-06741 50mg Ask for price

Recombinant Human GM-CSF Protein

PROTP04141-6 20ug
EUR 380.4
Description: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites.

Human GM-CSF Recombinant Protein

R00911-4 5ug/vial
EUR 310.8
Description: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a protein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Human GM-CSF Recombinant Protein is purified GM-CSF produced in yeast.

Mouse GM-CSF Recombinant Protein

R00911-5 5ug/vial
EUR 310.8
Description: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a protein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Mouse GM-CSF Recombinant Protein is purified GM-CSF produced in yeast.

Swine GM-CSF Recombinant Protein

R00911-7 5ug/vial
EUR 310.8
Description: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a protein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Swine GM-CSF Recombinant Protein is purified GM-CSF produced in yeast.

Recombinant Human GM-CSF Protein

E40KMP1980 20ug
EUR 495

Recombinant Murine GM-CSF Protein

PROTP01587-1 20ug
EUR 380.4
Description: GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant murine GM-CSF is a 14.2 kDa globular protein consisting of 125 amino acid residues.

Canine GM-CSF Recombinant Protein

R00911-1 5ug/vial
EUR 310.8
Description: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a protein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Canine GM-CSF Recombinant Protein is purified GM-CSF produced in yeast.

Equine GM-CSF Recombinant Protein

R00911-3 5ug/vial
EUR 310.8
Description: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a protein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Equine GM-CSF Recombinant Protein is purified GM-CSF produced in yeast

Rabbit GM-CSF Recombinant Protein

R00911-6 5ug/vial
EUR 310.8
Description: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a protein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts. GM-CSF stimulates stem cells to produce granulocytes and monocytes and is glycosylated in its mature form.

Recombinant Rhesus Macaque GM-CSF

EEOPP-0702 10ug Ask for price

CSF2RB GM-CSF Receptor Beta Human Recombinant Protein

PROTP32927 Regular: 10ug
EUR 380.4
Description: CSF2RB Human Recombinant produced in Sf9 Baculovirus cells is a single, glycosylated polypeptide chain containing 435 amino acids (17-443 a.a) and having a molecular mass of 49.7kDa. (Migrates at 40-57kDa on SDS-PAGE under reducing conditions). CSF2RB is fused to an 8 amino acid His-tag at C-terminus & purified by proprietary chromatographic techniques.

OPSD00007-5UG - Recombinant GM-CSF

OPSD00007-5UG 5ug
EUR 108

OPSD00113-5UG - Recombinant GM-CSF

OPSD00113-5UG 5ug
EUR 108

OPSD00157-5UG - Recombinant GM-CSF

OPSD00157-5UG 5ug
EUR 108

Chicken GM-CSF Recombinant Protein

R00911-2 5ug/vial
EUR 310.8
Description: Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a protein secreted by macrophages, T cells, mast cells, NK cells, endothelial cells and fibroblasts. GM-CSF stimulates stem cells to produce granulocytes (neutrophils, eosinophils, and basophils) and monocytes. Chicken GM-CSF Recombinant Protein is purified GM-CSF produced in yeast.

CSF2RA GM-CSF Receptor Alpha Human Recombinant Protein

PROTP15509 Regular: 20ug
EUR 380.4
Description: CSF2RA Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 324 amino acids (20-320 a.a) and having a molecular mass of 37.2kDa.

Recombinant Bovine Aprotinin

7-04417 1mg Ask for price

Recombinant Bovine Aprotinin

7-04418 20mg Ask for price

Recombinant Bovine Aprotinin

7-04419 100mg Ask for price

Recombinant Bovine IL-6

P0172 100ug
EUR 626.83
Description: Recombinant Bovine protein for IL-6

Recombinant Bovine IL-8

P0176 100ug
EUR 626.83
Description: Recombinant Bovine protein for IL-8

Recombinant Bovine PAI-1

P0141 100ug
EUR 626.83
Description: Recombinant Bovine protein for PAI-1

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