Complex impedance spectroscopy for monitoring tissue responses to inserted neural implants.

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April 28, 2021 0 Comments

Complex impedance spectroscopy for monitoring tissue responses to inserted neural implants.

A series of animal experiments was conducted to characterize changes in the complex impedance of chronically implanted electrodes in neural tissue. Consistent trends in impedance changes were observed across all animals, characterized as a general increase in the measured impedance magnitude at 1 kHz. Impedance changes reach a peak approximately 7 days post-implant. Reactive responses around individual electrodes were described using immuno– and histochemistry and confocal microscopy.
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These observations were compared to measured impedance changes. Several features of impedance changes were able to differentiate between confined and extensivehistological reactions. In general, impedance magnitude at 1 kHz was significantly increased in extensive reactions, starting about 4 days post-implant. Electrodes with extensive reactions also displayed impedance spectra with a characteristic change at high frequencies. This change was manifested in the formation of a semi-circular arc in the Nyquist space, suggestive of increased cellular density in close proximity to the electrode site. These results suggest that changes in impedance spectra are directly influenced by cellular distributions around implanted electrodes over time and that impedance measurements may provide an online assessment of cellular reactions to implanted devices.

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EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF594 conjugate, Concentration: 0.1mg/mL

MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody

BNC941553-100 100uL
EUR 233
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF594 conjugate, Concentration: 0.1mg/mL

MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody

BNC941553-500 500uL
EUR 545
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF594 conjugate, Concentration: 0.1mg/mL

MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody

BNCB1553-100 100uL
EUR 233
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), Biotin conjugate, Concentration: 0.1mg/mL

MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody

BNCB1553-500 500uL
EUR 545
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), Biotin conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNCH0432-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNCH0432-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody

BNCH1004-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody

BNCH1004-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody

BNCH1007-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody

BNCH1007-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody

BNCH1553-100 100uL
EUR 233
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody

BNCH1553-500 500uL
EUR 545
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNC800432-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF680 conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNC800432-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF680 conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody

BNC801004-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF680 conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody

BNC801004-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF680 conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody

BNC801007-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF680 conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody

BNC801007-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF680 conjugate, Concentration: 0.1mg/mL

MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody

BNC801553-100 100uL
EUR 233
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF680 conjugate, Concentration: 0.1mg/mL

MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody

BNC801553-500 500uL
EUR 545
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF680 conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNC810432-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF680R conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNC810432-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF680R conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNCP0432-250 250uL
EUR 383
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), PerCP conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody

BNCP1004-250 250uL
EUR 383
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), PerCP conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody

BNCP1007-250 250uL
EUR 383
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), PerCP conjugate, Concentration: 0.1mg/mL

MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody

BNCP1553-250 250uL
EUR 394
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), PerCP conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNCR0432-250 250uL
EUR 383
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), RPE conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody

BNCR1004-250 250uL
EUR 383
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), RPE conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody

BNCR1007-250 250uL
EUR 383
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), RPE conjugate, Concentration: 0.1mg/mL

MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody

BNCR1553-250 250uL
EUR 394
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), RPE conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNCA0432-250 250uL
EUR 383
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), APC conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody

BNCA1004-250 250uL
EUR 383
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), APC conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody

BNCA1007-250 250uL
EUR 383
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), APC conjugate, Concentration: 0.1mg/mL

MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody

BNCA1553-250 250uL
EUR 394
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), APC conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNCAP0432-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNCAP0432-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody

BNCAP1004-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody

BNCAP1004-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody

BNCAP1007-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody

BNCAP1007-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody

BNCAP1553-100 100uL
EUR 233
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody

BNCAP1553-500 500uL
EUR 545
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNCB0432-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), Biotin conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNCB0432-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), Biotin conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody

BNCB1004-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), Biotin conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody

BNCB1004-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), Biotin conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody

BNCB1007-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), Biotin conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody

BNCB1007-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), Biotin conjugate, Concentration: 0.1mg/mL

MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody

BNC811553-100 100uL
EUR 233
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF680R conjugate, Concentration: 0.1mg/mL

MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody

BNC811553-500 500uL
EUR 545
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF680R conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNC880432-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF488A conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNC880432-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF488A conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody

BNC881004-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF488A conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody

BNC881004-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF488A conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody

BNC881007-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF488A conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody

BNC881007-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF488A conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNUB0432-100 100uL
EUR 209
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), Concentration: 0.2mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody

BNUB0432-500 500uL
EUR 458
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), Concentration: 0.2mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody

BNC811004-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF680R conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody

BNC811004-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF680R conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody

BNC811007-100 100uL
EUR 199
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF680R conjugate, Concentration: 0.1mg/mL

MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody

BNC811007-500 500uL
EUR 544
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF680R conjugate, Concentration: 0.1mg/mL

Anti-MUC5AC (Mucin 5AC/Gastric Mucin) Monoclonal Antibody

M00612 100ug/vial
EUR 397
Description: Mouse Monoclonal MUC5AC (Mucin 5AC/Gastric Mucin) Antibody. Validated in IHC and tested in Chicken, Human, Monkey, Mouse, Pig, Rabbit, Rat.

Anti-MUC6 (Mucin 6 / Gastric Mucin) Monoclonal Antibody

M02143 100ug/vial
EUR 397
Description: Mouse Monoclonal MUC6 (Mucin 6 / Gastric Mucin) Antibody. Validated in IHC and tested in Human.

MUC5AC (Mucin 5AC / Gastric Mucin); Clone 45M1 (Concentrate)

RA0221-C.1 0.1 ml
EUR 125

MUC5AC (Mucin 5AC / Gastric Mucin); Clone 45M1 (Concentrate)

RA0221-C.5 0.5 ml
EUR 300

MUC5AC (Mucin 5AC / Gastric Mucin); Clone CLH2 (Concentrate)

RA0222-C.1 0.1 ml
EUR 125

MUC5AC (Mucin 5AC / Gastric Mucin); Clone CLH2 (Concentrate)

RA0222-C.5 0.5 ml
EUR 300

MUC6 (Mucin 6 / Gastric Mucin); Clone CLH5 (Concentrate)

RA0224-C.1 0.1 ml
EUR 125

MUC6 (Mucin 6 / Gastric Mucin); Clone CLH5 (Concentrate)

RA0224-C.5 0.5 ml
EUR 300

Monoclonal MUC5AC (Mucin 5AC / Gastric Mucin) Antibody, Clone: 45M1

AMM01094G 7 ml
EUR 484
Description: A Monoclonal antibody against Human MUC5AC (Mucin 5AC / Gastric Mucin). The antibodies are raised in Mouse and are from clone 45M1. This antibody is applicable in IHC, IF, FC

Monoclonal MUC5AC (Mucin 5AC / Gastric Mucin) Antibody, Clone: SPM297

AMM01095G 7 ml
EUR 484
Description: A Monoclonal antibody against Human MUC5AC (Mucin 5AC / Gastric Mucin). The antibodies are raised in Mouse and are from clone SPM297. This antibody is applicable in IHC, IF, FC

Monoclonal MUC5AC (Mucin 5AC / Gastric Mucin) Antibody, Clone: 58M1

AMM01098G 7 ml
EUR 484
Description: A Monoclonal antibody against Human MUC5AC (Mucin 5AC / Gastric Mucin). The antibodies are raised in Mouse and are from clone 58M1. This antibody is applicable in IHC, IF, FC

Monoclonal MUC5AC (Mucin 5AC / Gastric Mucin) Antibody, Clone: CLH2

AMM01103G 7 ml
EUR 484
Description: A Monoclonal antibody against Human MUC5AC (Mucin 5AC / Gastric Mucin). The antibodies are raised in Mouse and are from clone CLH2. This antibody is applicable in IHC, IF, FC

Monoclonal MUC5AC (Mucin 5AC / Gastric Mucin) Antibody, Clone: SPM488

AMM01106G 7 ml
EUR 484
Description: A Monoclonal antibody against Human MUC5AC (Mucin 5AC / Gastric Mucin). The antibodies are raised in Mouse and are from clone SPM488. This antibody is applicable in IHC, IF, FC

Monoclonal MUC6 (Mucin 6 / Gastric Mucin) Antibody, Clone: CLH5

AMM01117G 7 ml
EUR 484
Description: A Monoclonal antibody against Human MUC6 (Mucin 6 / Gastric Mucin). The antibodies are raised in Mouse and are from clone CLH5. This antibody is applicable in IHC, IF, FC

Monoclonal MUC6 (Mucin 6 / Gastric Mucin) Antibody, Clone: SPM598

AMM01120G 7 ml
EUR 484
Description: A Monoclonal antibody against Human MUC6 (Mucin 6 / Gastric Mucin). The antibodies are raised in Mouse and are from clone SPM598. This antibody is applicable in IHC, IF, FC

MUC5AC (Mucin 5AC / Gastric Mucin); Clone MUC5AC/917 (Concentrate)

RA0223-C.1 0.1 ml
EUR 125

MUC5AC (Mucin 5AC / Gastric Mucin); Clone MUC5AC/917 (Concentrate)

RA0223-C.5 0.5 ml
EUR 300

MUC6 (Mucin 6 / Gastric Mucin); Clone MUC6/916 (Concentrate)

RA0225-C.1 0.1 ml
EUR 125

MUC6 (Mucin 6 / Gastric Mucin); Clone MUC6/916 (Concentrate)

RA0225-C.5 0.5 ml
EUR 300

Human Gastric Mucin(GM)ELISA Kit

GA-E1401HM-48T 48T
EUR 289

Human Gastric Mucin(GM)ELISA Kit

GA-E1401HM-96T 96T
EUR 466

MUC5AC (Gastric Mucin); Clone 45M1 (Concentrate)

A00124-C 1 ml
EUR 437

259 Patients with DCIS of the breast applying USC/Van Nuys prognostic index: a retrospective review with long term follow up.

BACKGROUND
The Van Nuys Prognostic Index (VNPI) is a simple score for predicting the risk of local recurrence (LR) in patients with Ductal Carcinoma In Situ (DCIS) conservatively treated. This score combines three independent predictors of Local Recurrence. The VNPI has recently been updated with the addition of age as a fourth parameter into the scoring system (University of Southern California/ VNPI).
METHODS
Our database consisted of 408 women with DCIS. Applying the USC/VNPI we reviewed retrospectively 259 patients who were treated with breast conserving surgery with or without radiotherapy (RT). Of these patients 63.5% had a low VNPI score, 32% intermediate and 4.5% a high score. In the low score group, the majority of the patients underwent Conservative Surgery (CS) without RT while in the intermediate group, almost half of the patients received RT. Eighty-three percent (83%) of the patients with high VNPI were treated with Conservative Surgery plus RT. Nodal assessment by Sentinel Lymph Node Biopsy was obtained in 32 patients since 2002.
RESULTS
Twenty-one Local Recurrences were observed (8%) with a mean follow up of 130 months: sixteen were invasive. No statistically significant differences in Disease Free Survival were reached in all groups of VNPI score between patients treated with Conservative Surgery or Conservative Surgery plus RT. However it was noted that the higher the VNPI score, the lower was the risk of local recurrence in the group treated additionally with RT, even though it was not statistically significant. Further analysis included those patients treated with Conservative Surgery alone and followed up. Disease-free survival (DFS) at 10 years was 94% with low VNPI and 83% in both intermediate and high score (P < 0.05). No significant differences were observed in the subgroups of VNPI.
The Local Relapse rate after Conservative Surgery alone, increased with tumor size, margin width, and pathology classification (P < 0,05), while age was not found to be a significant factor. Lesions with only mammographic appearances are associated with lower DFS but it did not reach significance (P = ns), while assumption of estrogenic hormones and familial history of breast cancer are significant factors associated with a higher risk of local recurrence. After multivariate analysis including seven clinical and pathological factors, the only significant predictors of local recurrence remained margin width of surgical excision, previous therapy with estrogens (contraceptives or Hormone Replacement Therapy) and the Van Nuys pathologic classification.
The overall survival breast cancer specific was 99% and no differences were observed between groups (P = ns). The comparison of patients treated with a total mastectomy and those conservatively treated showed a significantly better local relapse free survival rate obtained with mastectomy (98.2% vs. 89.7% at 10 years P = 0.02). However, the overall cause-specific survival did not prove any better outcome (98.7% in both groups). Of the 32 patients who underwent a Sentinel Lymph Node Biopsy, four were found to have micrometastases and all of them had a previous Directional Vacuum Assisted Biopsy.
CONCLUSIONS
Although in our series there is not a significant difference in LR rates by the parameter of age, the new USC/VNPI is still a simple and reliable scoring system for therapeutic management of DCIS. We did not find any statistically significant advantage in groups treated with the addition of RT. Obtaining wide surgical margins appears to be the strongest prognostic factor for local recurrence, regardless of other pathological factors or the addition of adjuvant radiation therapy. However, only prospective randomized studies can precisely predict the risk of LR of conservatively treated DCIS.
The clinical significance of Sentinel Lymph Nodes micrometastases ImmunoHistoChemistry-detected found in DCIS patients remains uncertain. However, we hypothesize that the anatomical disruption after preoperative biopsy procedures increases the likelihood of epithelial cell displacement and the frequency of IHC-positive Sentinel Lymph Nodes, both of which are directly proportional to the degree of manipulation.

Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat.

BACKGROUND
Notwithstanding increasing knowledge of titanium dioxide nanoparticles (TiO2 NPs) passing through biological barriers, their biodistribution to the central nervous system (CNS) and potential effects on blood-brain barrier (BBB) physiology remain poorly characterized.
METHODS
Here, we report time-related responses from single-dose intravenous (IV) administration of 1 mg/kg TiO2 NPs to rats, with particular emphasis on titanium (Ti) quantification in the brain. Ti content in tissues was analyzed using inductively coupled plasma mass spectrometry. Integrity and functionality of the BBB as well as brain inflammation were characterized using a panel of methods including RT-PCR, immunohisto chemistry and transporter activity evaluation.
RESULTS
Biokinetic analysis revealed Ti biopersistence in liver, lungs and spleen up to one year after TiO2 NPs administration. A significant increase of Ti in the brain was observed at early end points followed by a subsequent decrease. In-depth analysis of Ti in the total brain demonstrated quantitative Ti uptake and clearance by brain microvasculature endothelial cells (BECs) with minimal translocation in the brain parenchyma. The presence of Ti in the BECs did not affect BBB integrity, despite rapid reversible modulation of breast cancer resistance protein activity.
Ti biopersistence in organs such as liver was associated with significant increases of tight junction proteins (claudin-5 and occludin), interleukin 1β (IL-1β), chemokine ligand 1 (CXCL1) and γ inducible protein-10 (IP-10/CXCL10) in BECs and also increased levels of IL-1β in brain parenchyma despite lack of evidence of Ti in the brain. These findings mentioned suggest potential effect of Ti present at a distance from the brain possibly via mediators transported by blood. Exposure of an in vitro BBB model to sera from TiO2 NPs-treated animals confirmed the tightness of the BBB and inflammatory responses.
CONCLUSIONS
Overall, these findings suggest the clearance of TiO2 NPs at the BBB with persistent brain inflammation and underscore the role of Ti biopersistence in organs that can exert indirect effects on the CNS dependent on circulating factors.

Recombinant Nestin (NES)

4-RPA500Hu01
  • EUR 413.60
  • EUR 214.00
  • EUR 1276.00
  • EUR 492.00
  • EUR 884.00
  • EUR 340.00
  • EUR 3040.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P48681
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 28.5kDa
  • Isoelectric Point: 10.3
Description: Recombinant Human Nestin expressed in: E.coli

Recombinant Nestin (NES)

4-RPA500Mu01
  • EUR 503.20
  • EUR 238.00
  • EUR 1612.00
  • EUR 604.00
  • EUR 1108.00
  • EUR 400.00
  • EUR 3880.00
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: Q6P5H2
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 61.0kDa
  • Isoelectric Point: Inquire
Description: Recombinant Mouse Nestin expressed in: E.coli

Recombinant Nestin (NES)

4-RPA500Ra01
  • EUR 510.37
  • EUR 239.00
  • EUR 1638.88
  • EUR 612.96
  • EUR 1125.92
  • EUR 404.00
  • EUR 3947.20
  • 100 ug
  • 10ug
  • 1 mg
  • 200 ug
  • 500 ug
  • 50ug
  • 5 mg
  • Uniprot ID: P21263
  • Buffer composition: PBS, pH 7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
  • Form: Freeze-dried powder
  • Predicted Molecular Mass (KD): 32.9kDa
  • Isoelectric Point: Inquire
Description: Recombinant Rat Nestin expressed in: E.coli

Nestin

GT15114 100 ug
EUR 526

Nestin

CH22123 100 ul
EUR 409

Nestin

CH23001 100 ul
EUR 179

Nestin

MO15012 100 ug
EUR 448

Nestin

MO15056 100 ug
EUR 435

Nestin

MO22183 100 ug
EUR 435

Nestin

RA22125 100 ul
EUR 435

Nestin/ Rat Nestin ELISA Kit

ELA-E2175r 96 Tests
EUR 886

Mouse Anti-Human Nestin monoclonal antibody, clone JID749

CABT-L3001-100uL500uL 100 uL, 500 uL
EUR 502

Nestin antibody

70R-5230 50 ug
EUR 467
Description: Rabbit polyclonal Nestin antibody raised against the middle region of NES

Nestin antibody

70R-NR017 100 ug
EUR 300
Description: Affinity purified Rabbit polyclonal Nestin antibody

Nestin Antibody

ABD7754 100 ug
EUR 438

Nestin Antibody

45133-100ul 100ul
EUR 252

Nestin Antibody

45133-50ul 50ul
EUR 187

Nestin Antibody

49032-100ul 100ul
EUR 333

Nestin Antibody

49032-50ul 50ul
EUR 239

Nestin antibody

10R-6669 100 ug
EUR 478
Description: Mouse monoclonal Nestin antibody

Nestin antibody

10R-8096 100 ug
EUR 440
Description: Mouse monoclonal Nestin antibody

Nestin antibody

10R-8364 100 ul
EUR 349
Description: Mouse monoclonal Nestin antibody

Nestin Antibody

3208-100
EUR 359

Nestin antibody

70R-10645 1 ml
EUR 693
Description: Affinity purified Chicken polyclonal Nestin antibody

Nestin antibody

70R-11692 100 ug
EUR 459
Description: Rabbit polyclonal Nestin antibody

Nestin Antibody

DF7754 200ul
EUR 304
Description: Nestin Antibody detects endogenous levels of total Nestin.

Nestin (NES) Polyclonal Antibody (Human)

4-PAA500Hu01
  • EUR 232.00
  • EUR 2285.00
  • EUR 574.00
  • EUR 289.00
  • EUR 208.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Leu178~Pro399)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Nestin (NES)

Nestin (NES) Polyclonal Antibody (Mouse)

4-PAA500Mu01
  • EUR 236.00
  • EUR 2338.00
  • EUR 586.00
  • EUR 294.00
  • EUR 209.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Arg197~Pro462)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES)

Nestin (NES) Polyclonal Antibody (Rat)

4-PAA500Ra01
  • EUR 243.00
  • EUR 2457.00
  • EUR 613.00
  • EUR 305.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Arg197~Asn462)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Nestin (NES)

Human Nestin (NES) ELISA Kit

SEA500Hu-10x96wellstestplate 10x96-wells test plate
EUR 4273.35
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Nestin (NES) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Nestin (NES) in tissue homogenates, cell lysates and other biological fluids.

Human Nestin (NES) ELISA Kit

SEA500Hu-1x48wellstestplate 1x48-wells test plate
EUR 439.57
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Nestin (NES) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Nestin (NES) in tissue homogenates, cell lysates and other biological fluids.

Human Nestin (NES) ELISA Kit

SEA500Hu-1x96wellstestplate 1x96-wells test plate
EUR 585.1
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Nestin (NES) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Nestin (NES) in tissue homogenates, cell lysates and other biological fluids.

Human Nestin (NES) ELISA Kit

SEA500Hu-5x96wellstestplate 5x96-wells test plate
EUR 2332.95
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Human Nestin (NES) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Nestin (NES) in tissue homogenates, cell lysates and other biological fluids.

Human Nestin (NES) ELISA Kit

4-SEA500Hu
  • EUR 4324.00
  • EUR 2283.00
  • EUR 586.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
  • Known also as Nestin elisa. Alternative names of the recognized antigen: n/a
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Nestin (NES) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Mouse Nestin (NES) ELISA Kit

SEA500Mu-10x96wellstestplate 10x96-wells test plate
EUR 4391.16
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Nestin (NES) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Nestin (NES) in tissue homogenates, cell lysates and other biological fluids.

Mouse Nestin (NES) ELISA Kit

SEA500Mu-1x48wellstestplate 1x48-wells test plate
EUR 449.27
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Nestin (NES) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Nestin (NES) in tissue homogenates, cell lysates and other biological fluids.

Mouse Nestin (NES) ELISA Kit

SEA500Mu-1x96wellstestplate 1x96-wells test plate
EUR 598.96
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Nestin (NES) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Nestin (NES) in tissue homogenates, cell lysates and other biological fluids.

Mouse Nestin (NES) ELISA Kit

SEA500Mu-5x96wellstestplate 5x96-wells test plate
EUR 2395.32
  • The Intra-assay Precision is determined when 3 samples with low, middle and high level of Mouse Nestin (NES) were tested on 3 different plates, 8 replicates in each plate
  • CV(%) = SD/meanX100
  • Intra-Assay: CV<10%
  • Inter-Assay: CV<12%
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Nestin (NES) in tissue homogenates, cell lysates and other biological fluids.

Mouse Nestin (NES) ELISA Kit

4-SEA500Mu
  • EUR 4442.00
  • EUR 2346.00
  • EUR 599.00
  • 10 plates of 96 wells
  • 5 plates of 96 wells
  • 1 plate of 96 wells
  • Known also as Nestin elisa. Alternative names of the recognized antigen: n/a
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Nestin (NES) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.

Rabbit Anti-Human Nestin monoclonal antibody, clone TO17-38

DCABH-6339 100 ul
EUR 777

Nestin (NES) Polyclonal Antibody (Human), APC

4-PAA500Hu01-APC
  • EUR 323.00
  • EUR 2969.00
  • EUR 836.00
  • EUR 409.00
  • EUR 210.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Leu178~Pro399)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Nestin (NES). This antibody is labeled with APC.

Nestin (NES) Polyclonal Antibody (Human), Biotinylated

4-PAA500Hu01-Biotin
  • EUR 295.00
  • EUR 2235.00
  • EUR 671.00
  • EUR 358.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Leu178~Pro399)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Nestin (NES). This antibody is labeled with Biotin.

Nestin (NES) Polyclonal Antibody (Human), Cy3

4-PAA500Hu01-Cy3
  • EUR 390.00
  • EUR 3917.00
  • EUR 1073.00
  • EUR 504.00
  • EUR 239.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Leu178~Pro399)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Nestin (NES). This antibody is labeled with Cy3.

Nestin (NES) Polyclonal Antibody (Human), FITC

4-PAA500Hu01-FITC
  • EUR 279.00
  • EUR 2395.00
  • EUR 688.00
  • EUR 347.00
  • EUR 188.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Leu178~Pro399)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Nestin (NES). This antibody is labeled with FITC.

Nestin (NES) Polyclonal Antibody (Human), HRP

4-PAA500Hu01-HRP
  • EUR 297.00
  • EUR 2589.00
  • EUR 741.00
  • EUR 371.00
  • EUR 199.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Leu178~Pro399)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Nestin (NES). This antibody is labeled with HRP.

Nestin (NES) Polyclonal Antibody (Human), PE

4-PAA500Hu01-PE
  • EUR 279.00
  • EUR 2395.00
  • EUR 688.00
  • EUR 347.00
  • EUR 188.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Leu178~Pro399)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Nestin (NES). This antibody is labeled with PE.

Nestin (NES) Polyclonal Antibody (Mouse), APC

4-PAA500Mu01-APC
  • EUR 329.00
  • EUR 3041.00
  • EUR 854.00
  • EUR 416.00
  • EUR 212.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Arg197~Pro462)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES). This antibody is labeled with APC.

Nestin (NES) Polyclonal Antibody (Mouse), Biotinylated

4-PAA500Mu01-Biotin
  • EUR 299.00
  • EUR 2288.00
  • EUR 684.00
  • EUR 363.00
  • EUR 214.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Arg197~Pro462)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES). This antibody is labeled with Biotin.

Nestin (NES) Polyclonal Antibody (Mouse), Cy3

4-PAA500Mu01-Cy3
  • EUR 397.00
  • EUR 4013.00
  • EUR 1097.00
  • EUR 513.00
  • EUR 241.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Arg197~Pro462)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES). This antibody is labeled with Cy3.

Nestin (NES) Polyclonal Antibody (Mouse), FITC

4-PAA500Mu01-FITC
  • EUR 283.00
  • EUR 2452.00
  • EUR 703.00
  • EUR 353.00
  • EUR 189.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Arg197~Pro462)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES). This antibody is labeled with FITC.

Nestin (NES) Polyclonal Antibody (Mouse), HRP

4-PAA500Mu01-HRP
  • EUR 302.00
  • EUR 2652.00
  • EUR 756.00
  • EUR 377.00
  • EUR 200.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Arg197~Pro462)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES). This antibody is labeled with HRP.

Nestin (NES) Polyclonal Antibody (Mouse), PE

4-PAA500Mu01-PE
  • EUR 283.00
  • EUR 2452.00
  • EUR 703.00
  • EUR 353.00
  • EUR 189.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Arg197~Pro462)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES). This antibody is labeled with PE.

Nestin (NES) Polyclonal Antibody (Rat), APC

4-PAA500Ra01-APC
  • EUR 340.00
  • EUR 3203.00
  • EUR 894.00
  • EUR 432.00
  • EUR 217.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Arg197~Asn462)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Nestin (NES). This antibody is labeled with APC.

Nestin (NES) Polyclonal Antibody (Rat), Biotinylated

4-PAA500Ra01-Biotin
  • EUR 307.00
  • EUR 2407.00
  • EUR 714.00
  • EUR 375.00
  • EUR 217.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Arg197~Asn462)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Nestin (NES). This antibody is labeled with Biotin.

Nestin (NES) Polyclonal Antibody (Rat), Cy3

4-PAA500Ra01-Cy3
  • EUR 411.00
  • EUR 4229.00
  • EUR 1151.00
  • EUR 535.00
  • EUR 248.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Arg197~Asn462)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Nestin (NES). This antibody is labeled with Cy3.

Nestin (NES) Polyclonal Antibody (Rat), FITC

4-PAA500Ra01-FITC
  • EUR 292.00
  • EUR 2582.00
  • EUR 735.00
  • EUR 366.00
  • EUR 194.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Arg197~Asn462)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Nestin (NES). This antibody is labeled with FITC.

Nestin (NES) Polyclonal Antibody (Rat), HRP

4-PAA500Ra01-HRP
  • EUR 311.00
  • EUR 2792.00
  • EUR 791.00
  • EUR 391.00
  • EUR 205.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Arg197~Asn462)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Nestin (NES). This antibody is labeled with HRP.

Nestin (NES) Polyclonal Antibody (Rat), PE

4-PAA500Ra01-PE
  • EUR 292.00
  • EUR 2582.00
  • EUR 735.00
  • EUR 366.00
  • EUR 194.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Arg197~Asn462)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Nestin (NES). This antibody is labeled with PE.

Nestin (NES) Monoclonal Antibody (Human, Rat)

4-MAA500Hu21
  • EUR 241.00
  • EUR 2417.00
  • EUR 604.00
  • EUR 301.00
  • EUR 211.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Leu178~Pro399
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES)

Nestin (NES) Monoclonal Antibody (Human, Rat)

4-MAA500Hu22
  • EUR 241.00
  • EUR 2417.00
  • EUR 604.00
  • EUR 301.00
  • EUR 211.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Leu178~Pro399
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES)

Polyclonal Nestin Antibody

APR00047G 0.1mg
EUR 484
Description: A polyclonal antibody raised in Rabbit that recognizes and binds to Human Nestin . This antibody is tested and proven to work in the following applications:

Polyclonal Nestin Antibody

APC00036G 0.1mg
EUR 528
Description: A polyclonal antibody raised in Chicken that recognizes and binds to Human Nestin . This antibody is tested and proven to work in the following applications:

Nestin Conjugated Antibody

C45133 100ul
EUR 397

anti- Nestin antibody

FNab05664 100µg
EUR 505.25
  • Recommended dilution: WB: 1:500-1:2000
  • IHC: 1:20-1:1000
  • IF: 1:20-1:200
  • Immunogen: nestin
  • Uniprot ID: P48681
  • Gene ID: 10763
  • Research Area: Cardiovascular, Immunology, Cancer, Developmental biology, Neuroscience, Stem Cells
Description: Antibody raised against Nestin

Nestin (NES) Antibody

20-abx126235
  • EUR 411.00
  • EUR 592.00
  • EUR 182.00
  • EUR 314.00
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul
  • Shipped within 5-10 working days.

Nestin (NES) Antibody

20-abx130385
  • EUR 425.00
  • EUR 133.00
  • EUR 1177.00
  • EUR 578.00
  • EUR 328.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Nestin (NES) Antibody

20-abx132115
  • EUR 314.00
  • EUR 787.00
  • EUR 411.00
  • EUR 154.00
  • EUR 258.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

NESTIN (NES) Antibody

abx122535-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

NESTIN (NES) Antibody

abx122536-100ug 100 ug
EUR 391
  • Shipped within 5-10 working days.

Nestin (NES) Antibody

20-abx000729
  • EUR 411.00
  • EUR 592.00
  • 100 ul
  • 200 ul
  • Shipped within 5-10 working days.

Nestin (NES) Antibody

20-abx132401
  • EUR 314.00
  • EUR 787.00
  • EUR 411.00
  • EUR 154.00
  • EUR 258.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-7 working days.

Nestin (NES) Antibody

20-abx100056
  • EUR 398.00
  • EUR 133.00
  • EUR 1107.00
  • EUR 537.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Nestin (NES) Antibody

20-abx100057
  • EUR 411.00
  • EUR 133.00
  • EUR 1135.00
  • EUR 551.00
  • EUR 314.00
  • 100 ug
  • 10 ug
  • 1 mg
  • 200 ug
  • 50 ug
  • Shipped within 5-7 working days.

Nestin (NES) Antibody

abx031445-400ul 400 ul
EUR 523
  • Shipped within 5-10 working days.

Nestin (NES) Antibody

abx031445-80l 80 µl
EUR 286
  • Shipped within 5-10 working days.

Nestin (NES) Antibody

abx015937-100ul 100 ul
EUR 411
  • Shipped within 5-10 working days.

Nestin (NES) Antibody

abx015938-100ug 100 ug
EUR 411
  • Shipped within 5-10 working days.

Nestin (NES) Antibody

20-abx177737
  • EUR 1135.00
  • EUR 551.00
  • 1 mg
  • 200 ug
  • Please enquire.

Nestin (NES) Antibody

20-abx217112
  • EUR 425.00
  • EUR 342.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Nestin (NES) Antibody

20-abx339203
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Nestin (NES) Antibody

20-abx339336
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Nestin (NES) Antibody

abx235664-100ug 100 ug
EUR 481
  • Shipped within 5-12 working days.

Nestin (NES) Antibody

20-abx301028
  • EUR 411.00
  • EUR 1845.00
  • EUR 599.00
  • EUR 182.00
  • EUR 300.00
  • 100 ug
  • 1 mg
  • 200 ug
  • 20 ug
  • 50 ug
  • Shipped within 5-10 working days.

Nestin (NES) Antibody

20-abx210113
  • EUR 439.00
  • EUR 328.00
  • 100 ug
  • 50 ug
  • Shipped within 5-10 working days.

Nestin (NES) Antibody

20-abx210684
  • EUR 411.00
  • EUR 300.00
  • 100 ul
  • 50 ul
  • Shipped within 5-10 working days.

Nestin Rabbit pAb

A11861-100ul 100 ul
EUR 308

Nestin Rabbit pAb

A11861-200ul 200 ul
EUR 459

Nestin Rabbit pAb

A11861-20ul 20 ul
EUR 183

Nestin Rabbit pAb

A11861-50ul 50 ul
EUR 223

Nestin Blocking Peptide

33R-5261 100 ug
EUR 180
Description: A synthetic peptide for use as a blocking control in assays to test for specificity of NES antibody, catalog no. 70R-5230

Nestin Monoclonal Antibody

42024-100ul 100ul
EUR 333

Nestin Blocking Peptide

DF7754-BP 1mg
EUR 195

Anti-Nestin Antibody

PB9874 100ug/vial
EUR 334

Anti-Nestin antibody

STJ120141 100 µl
EUR 526

Nestin (NES) Polyclonal Antibody (Human), APC-Cy7

4-PAA500Hu01-APC-Cy7
  • EUR 527.00
  • EUR 5818.00
  • EUR 1552.00
  • EUR 698.00
  • EUR 301.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Leu178~Pro399)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Human Nestin (NES). This antibody is labeled with APC-Cy7.

Nestin (NES) Polyclonal Antibody (Mouse), APC-Cy7

4-PAA500Mu01-APC-Cy7
  • EUR 538.00
  • EUR 5962.00
  • EUR 1588.00
  • EUR 713.00
  • EUR 304.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Arg197~Pro462)
  • Buffer composition: PBS, pH7.4, containing 0.02% NaN3, 50% glycerol.
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES). This antibody is labeled with APC-Cy7.

Nestin (NES) Polyclonal Antibody (Rat), APC-Cy7

4-PAA500Ra01-APC-Cy7
  • EUR 560.00
  • EUR 6286.00
  • EUR 1669.00
  • EUR 745.00
  • EUR 315.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: NES (Arg197~Asn462)
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Rabbit polyclonal antibody against Rat Nestin (NES). This antibody is labeled with APC-Cy7.

Nestin (NES) Monoclonal Antibody (Human, Rat), APC

4-MAA500Hu21-APC
  • EUR 336.00
  • EUR 3149.00
  • EUR 881.00
  • EUR 427.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Leu178~Pro399
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with APC.

Nestin (NES) Monoclonal Antibody (Human, Rat), Biotinylated

4-MAA500Hu21-Biotin
  • EUR 305.00
  • EUR 2367.00
  • EUR 704.00
  • EUR 371.00
  • EUR 216.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Leu178~Pro399
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with Biotin.

Nestin (NES) Monoclonal Antibody (Human, Rat), Cy3

4-MAA500Hu21-Cy3
  • EUR 407.00
  • EUR 4157.00
  • EUR 1133.00
  • EUR 528.00
  • EUR 246.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Leu178~Pro399
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with Cy3.

Nestin (NES) Monoclonal Antibody (Human, Rat), FITC

4-MAA500Hu21-FITC
  • EUR 289.00
  • EUR 2539.00
  • EUR 724.00
  • EUR 361.00
  • EUR 192.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Leu178~Pro399
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with FITC.

Nestin (NES) Monoclonal Antibody (Human, Rat), HRP

4-MAA500Hu21-HRP
  • EUR 308.00
  • EUR 2745.00
  • EUR 780.00
  • EUR 387.00
  • EUR 203.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Leu178~Pro399
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with HRP.

Nestin (NES) Monoclonal Antibody (Human, Rat), PE

4-MAA500Hu21-PE
  • EUR 289.00
  • EUR 2539.00
  • EUR 724.00
  • EUR 361.00
  • EUR 192.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Leu178~Pro399
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with PE.

Nestin (NES) Monoclonal Antibody (Human, Rat), APC

4-MAA500Hu22-APC
  • EUR 336.00
  • EUR 3149.00
  • EUR 881.00
  • EUR 427.00
  • EUR 215.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Leu178~Pro399
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with APC.

Nestin (NES) Monoclonal Antibody (Human, Rat), Biotinylated

4-MAA500Hu22-Biotin
  • EUR 305.00
  • EUR 2367.00
  • EUR 704.00
  • EUR 371.00
  • EUR 216.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Leu178~Pro399
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with Biotin.

Nestin (NES) Monoclonal Antibody (Human, Rat), Cy3

4-MAA500Hu22-Cy3
  • EUR 407.00
  • EUR 4157.00
  • EUR 1133.00
  • EUR 528.00
  • EUR 246.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Leu178~Pro399
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with Cy3.

Nestin (NES) Monoclonal Antibody (Human, Rat), FITC

4-MAA500Hu22-FITC
  • EUR 289.00
  • EUR 2539.00
  • EUR 724.00
  • EUR 361.00
  • EUR 192.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Leu178~Pro399
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with FITC.

Nestin (NES) Monoclonal Antibody (Human, Rat), HRP

4-MAA500Hu22-HRP
  • EUR 308.00
  • EUR 2745.00
  • EUR 780.00
  • EUR 387.00
  • EUR 203.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Leu178~Pro399
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with HRP.

Nestin (NES) Monoclonal Antibody (Human, Rat), PE

4-MAA500Hu22-PE
  • EUR 289.00
  • EUR 2539.00
  • EUR 724.00
  • EUR 361.00
  • EUR 192.00
  • 100ul
  • 10ml
  • 1ml
  • 200ul
  • 20ul
  • Sequence of the immunogen: Leu178~Pro399
  • Buffer composition: 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with PE.

Nestin Conjugated Monoclonal Antibody

C42024 100ul
EUR 397

 

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