Complex impedance spectroscopy for monitoring tissue responses to inserted neural implants.
A series of animal experiments was conducted to characterize changes in the complex impedance of chronically implanted electrodes in neural tissue. Consistent trends in impedance changes were observed across all animals, characterized as a general increase in the measured impedance magnitude at 1 kHz. Impedance changes reach a peak approximately 7 days post-implant. Reactive responses around individual electrodes were described using immuno – and histo –chemistry and confocal microscopy.
antigenretrieve
These observations were compared to measured impedance changes. Several features of impedance changes were able to differentiate between confined and extensivehisto logical reactions. In general, impedance magnitude at 1 kHz was significantly increased in extensive reactions, starting about 4 days post-implant. Electrodes with extensive reactions also displayed impedance spectra with a characteristic change at high frequencies. This change was manifested in the formation of a semi-circular arc in the Nyquist space, suggestive of increased cellular density in close proximity to the electrode site. These results suggest that changes in impedance spectra are directly influenced by cellular distributions around implanted electrodes over time and that impedance measurements may provide an online assessment of cellular reactions to implanted devices.
Gastric Mucin
MA1043-S
Antagene
100μg
EUR 290
Description: Monoclonal Antibodies Conjugated to Sepharose
Gastric mucin
MBS5763571-5x5mg
MyBiosource
5x5mg
EUR 500
MUC4 (Mucin 4/Gastric Mucin)
MBS4381105-002mgWithBSAAzideat02mgmL
MyBiosource
0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230
MUC4 (Mucin 4/Gastric Mucin)
MBS4381105-01mgWithBSAAzideat02mgmL
MyBiosource
0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405
MUC4 (Mucin 4/Gastric Mucin)
MBS4381105-01mgWithoutBSAAzideat1mgmL
MyBiosource
0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405
MUC4 (Mucin 4/Gastric Mucin)
MBS4381105-5x01mgWithBSAAzideat02mgmL
MyBiosource
5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725
MUC4 (Mucin 4/Gastric Mucin)
MBS4381105-5x01mgWithoutBSAAzideat1mgmL
MyBiosource
5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725
MUC4 (Mucin 4/Gastric Mucin)
MBS4381106-002mgWithBSAAzideat02mgmL
MyBiosource
0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230
MUC4 (Mucin 4/Gastric Mucin)
MBS4381106-01mgWithBSAAzideat02mgmL
MyBiosource
0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405
MUC4 (Mucin 4/Gastric Mucin)
MBS4381106-01mgWithoutBSAAzideat1mgmL
MyBiosource
0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405
MUC4 (Mucin 4/Gastric Mucin)
MBS4381106-5x01mgWithBSAAzideat02mgmL
MyBiosource
5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725
MUC4 (Mucin 4/Gastric Mucin)
MBS4381106-5x01mgWithoutBSAAzideat1mgmL
MyBiosource
5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725
MUC6 (Mucin 6/Gastric Mucin)
MBS4380124-002mgWithBSAAzideat02mgmL
MyBiosource
0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230
MUC6 (Mucin 6/Gastric Mucin)
MBS4380124-01mgWithBSAAzideat02mgmL
MyBiosource
0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405
MUC6 (Mucin 6/Gastric Mucin)
MBS4380124-01mgWithoutBSAAzideat1mgmL
MyBiosource
0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405
MUC6 (Mucin 6/Gastric Mucin)
MBS4380124-5x01mgWithBSAAzideat02mgmL
MyBiosource
5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725
MUC6 (Mucin 6/Gastric Mucin)
MBS4380124-5x01mgWithoutBSAAzideat1mgmL
MyBiosource
5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725
MUC5AC (Mucin 5AC/Gastric Mucin)
MBS4381107-002mgWithBSAAzideat02mgmL
MyBiosource
0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230
MUC5AC (Mucin 5AC/Gastric Mucin)
MBS4381107-01mgWithBSAAzideat02mgmL
MyBiosource
0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405
MUC5AC (Mucin 5AC/Gastric Mucin)
MBS4381107-01mgWithoutBSAAzideat1mgmL
MyBiosource
0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405
MUC5AC (Mucin 5AC/Gastric Mucin)
MBS4381107-5x01mgWithBSAAzideat02mgmL
MyBiosource
5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725
MUC5AC (Mucin 5AC/Gastric Mucin)
MBS4381107-5x01mgWithoutBSAAzideat1mgmL
MyBiosource
5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725
MUC5AC (Mucin 5AC/Gastric Mucin)
MBS4381108-002mgWithBSAAzideat02mgmL
MyBiosource
0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230
MUC5AC (Mucin 5AC/Gastric Mucin)
MBS4381108-01mgWithBSAAzideat02mgmL
MyBiosource
0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405
MUC5AC (Mucin 5AC/Gastric Mucin)
MBS4381108-01mgWithoutBSAAzideat1mgmL
MyBiosource
0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405
MUC5AC (Mucin 5AC/Gastric Mucin)
MBS4381108-5x01mgWithBSAAzideat02mgmL
MyBiosource
5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725
MUC5AC (Mucin 5AC/Gastric Mucin)
MBS4381108-5x01mgWithoutBSAAzideat1mgmL
MyBiosource
5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725
MUC5AC (Mucin 5AC/Gastric Mucin)
MBS4381712-01mg
MyBiosource
0.1mg
EUR 410
MUC5AC (Mucin 5AC/Gastric Mucin)
MBS4381712-5x01mg
MyBiosource
5x0.1mg
EUR 1730
Mucin (gastric)
M32610
Pfaltz & Bauer
100G
EUR 658.64
Description: CAS N° 84082-64-4
Mucin gastric
MA1061
Antagene
100μg
EUR 260
Mucin gastric
MA1061-M
Antagene
100μg
EUR 290
Description: Monoclonal Antibodies Conjugated to Magnetic Beads
Mucin gastric
MA1061-S
Antagene
100μg
EUR 290
Description: Monoclonal Antibodies Conjugated to Sepharose
Gastric Mucin antibody
10R-7873
Fitzgerald
100 ug
EUR 519
Description: Mouse monoclonal Gastric Mucin antibody
Gastric Mucin antibody
MBS834531-01mg
MyBiosource
0.1mg
EUR 975
Gastric Mucin antibody
MBS834531-5x01mg
MyBiosource
5x0.1mg
EUR 4245
Gastric Mucin Mouse mAb
E2M50749
EnoGene
100ul
EUR 255
Description: Available in various conjugation types.
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNC701004-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF770 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNC701004-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF770 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNC701007-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF770 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNC701007-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF770 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNC800432-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF680 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNC800432-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF680 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNC801004-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF680 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNC801004-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF680 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNC801007-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF680 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNC801007-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF680 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNC810432-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF680R conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNC810432-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF680R conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNCA0432-250
Biotium
250uL
EUR 459.6
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), APC conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNCA1004-250
Biotium
250uL
EUR 459.6
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), APC conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNCA1007-250
Biotium
250uL
EUR 459.6
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), APC conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNC610432-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF660R conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNC610432-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF660R conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNC611004-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF660R conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNC611004-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF660R conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNC611007-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF660R conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNC611007-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF660R conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNC811004-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF680R conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNC811004-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF680R conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNC811007-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF680R conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNC811007-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF680R conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNC700432-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF770 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNC700432-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF770 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNCH0432-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNCH0432-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNCH1004-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNCH1004-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNCH1007-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNCH1007-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNCP0432-250
Biotium
250uL
EUR 459.6
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), PerCP conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNCP1004-250
Biotium
250uL
EUR 459.6
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), PerCP conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNCP1007-250
Biotium
250uL
EUR 459.6
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), PerCP conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNCR0432-250
Biotium
250uL
EUR 459.6
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), RPE conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNCR1004-250
Biotium
250uL
EUR 459.6
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), RPE conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNCR1007-250
Biotium
250uL
EUR 459.6
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), RPE conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNCAP1004-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNCAP1004-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNCAP1007-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNCAP1007-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNCAP0432-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNCAP0432-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNC430432-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF543 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNC430432-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF543 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNC431004-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF543 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNC431004-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF543 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNC431007-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF543 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNC431007-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF543 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNC050432-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF405M conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNC050432-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF405M conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNC051004-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF405M conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNC051004-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF405M conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNC051007-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF405M conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNC051007-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF405M conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNC550432-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF555 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (1-13M1) Antibody
BNC550432-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), CF555 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNC551004-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF555 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (9-13M1) Antibody
BNC551004-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), CF555 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNC551007-100
Biotium
100uL
EUR 238.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF555 conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin) (2-11M1) Antibody
BNC551007-500
Biotium
500uL
EUR 652.8
Description: Primary antibody against MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), CF555 conjugate, Concentration: 0.1mg/mL
Mucin Porcine Gastric Mucosa
MBS173674-100g
MyBiosource
100g
EUR 325
Mucin Porcine Gastric Mucosa
MBS173674-1kg
MyBiosource
1kg
EUR 1360
Mucin Porcine Gastric Mucosa
MBS173674-500g
MyBiosource
500g
EUR 930
Mucin Porcine Gastric Mucosa
MBS173674-5x1kg
MyBiosource
5x1kg
EUR 5955
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNC701553-100
Biotium
100uL
EUR 279.6
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF770 conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNC701553-500
Biotium
500uL
EUR 654
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF770 conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNC801553-100
Biotium
100uL
EUR 279.6
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF680 conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNC801553-500
Biotium
500uL
EUR 654
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF680 conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNCA1553-250
Biotium
250uL
EUR 472.8
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), APC conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNC551553-100
Biotium
100uL
EUR 279.6
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF555 conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNC551553-500
Biotium
500uL
EUR 654
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF555 conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNC611553-100
Biotium
100uL
EUR 279.6
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF660R conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNC611553-500
Biotium
500uL
EUR 654
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF660R conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNC811553-100
Biotium
100uL
EUR 279.6
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF680R conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNC811553-500
Biotium
500uL
EUR 654
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF680R conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNCP1553-250
Biotium
250uL
EUR 472.8
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), PerCP conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNCR1553-250
Biotium
250uL
EUR 472.8
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), RPE conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNUB1553-50
Biotium
50uL
EUR 486
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), 1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNCAP1553-100
Biotium
100uL
EUR 279.6
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNCAP1553-500
Biotium
500uL
EUR 654
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), Alkaline Phosphatase conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNCH1553-100
Biotium
100uL
EUR 279.6
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNCH1553-500
Biotium
500uL
EUR 654
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), Horseradish Peroxidase conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNC431553-100
Biotium
100uL
EUR 279.6
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF543 conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNC431553-500
Biotium
500uL
EUR 654
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF543 conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNC051553-100
Biotium
100uL
EUR 279.6
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF405M conjugate, Concentration: 0.1mg/mL
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R) Antibody
BNC051553-500
Biotium
500uL
EUR 654
Description: Primary antibody against MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), CF405M conjugate, Concentration: 0.1mg/mL
MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), 0.2mg/mL
BNUB0432-100
Biotium
100uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), 0.2mg/mL
BNUB0432-500
Biotium
500uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC5AC (Mucin 5AC / Gastric Mucin)(2-12M1), 0.2mg/mL
BNUB0438-100
Biotium
1uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC5AC (Mucin 5AC / Gastric Mucin)(2-12M1), 0.2mg/mL
BNUB0438-500
Biotium
1uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC5AC (Mucin 5AC / Gastric Mucin)(1-13M1), 1mg/mL
BNUM0432-50
Biotium
50uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC5AC (Mucin 5AC / Gastric Mucin)(2-12M1), 1mg/mL
BNUM0438-50
Biotium
1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), 1mg/mL
BNUM1004-50
Biotium
50uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), 1mg/mL
BNUM1007-50
Biotium
50uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), 0.2mg/mL
BNUB1004-100
Biotium
100uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC5AC (Mucin 5AC / Gastric Mucin)(9-13M1), 0.2mg/mL
BNUB1004-500
Biotium
500uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), 0.2mg/mL
BNUB1007-100
Biotium
100uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC5AC (Mucin 5AC / Gastric Mucin)(2-11M1), 0.2mg/mL
BNUB1007-500
Biotium
500uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC4 (Mucin 4 / Gastric Mucin)(MUC4/3084), 1mg/mL
BNUM3084-50
Biotium
1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC4 (Mucin 4 / Gastric Mucin)(MUC4/3105), 1mg/mL
BNUM3105-50
Biotium
1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC4 (Mucin 4 / Gastric Mucin)(MUC4/3084), 0.2mg/mL
BNUB3084-100
Biotium
1uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC4 (Mucin 4 / Gastric Mucin)(MUC4/3084), 0.2mg/mL
BNUB3084-500
Biotium
1uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC4 (Mucin 4 / Gastric Mucin)(MUC4/3105), 0.2mg/mL
BNUB3105-100
Biotium
1uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC4 (Mucin 4 / Gastric Mucin)(MUC4/3105), 0.2mg/mL
BNUB3105-500
Biotium
1uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC6 (Mucin 6 / Gastric Mucin)(MUC6/1553R), 1mg/mL
BNUM1553-50
Biotium
1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), 0.2mg/mL
BNUB1553-100
Biotium
100uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC6 (Mucin 6 / Gastric Mucin) (MUC6/1553R), 0.2mg/mL
BNUB1553-500
Biotium
500uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC6 (Mucin 6 / Gastric Mucin); Clone CLH5 (Concentrate)
RA0224-C.1
ScyTek Laboratories
0.1 ml
EUR 60.07
MUC6 (Mucin 6 / Gastric Mucin); Clone CLH5 (Concentrate)
RA0224-C.5
ScyTek Laboratories
0.5 ml
EUR 200.66
MUC5AC (Mucin 5AC / Gastric Mucin)(rMUC5AC/3779), 1mg/mL
BNUM3779-50
Biotium
1uL
EUR 396
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC5AC (Mucin 5AC / Gastric Mucin)(rMUC5AC/3779), 0.2mg/mL
BNUB3779-100
Biotium
1uL
EUR 225
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC5AC (Mucin 5AC / Gastric Mucin)(rMUC5AC/3779), 0.2mg/mL
BNUB3779-500
Biotium
1uL
EUR 485
Description: Primary and secondary antibodies for multiple methodologyimmunostaining detection application
MUC6 (Mucin 6 / Gastric Mucin) Mouse Monoclonal Antibody
MBS439748-002mgWithBSAAzideat02mgmL
MyBiosource
0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230
MUC6 (Mucin 6 / Gastric Mucin) Mouse Monoclonal Antibody
MBS439748-01mgWithBSAAzideat02mgmL
MyBiosource
0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405
MUC6 (Mucin 6 / Gastric Mucin) Mouse Monoclonal Antibody
MBS439748-01mgWithoutBSAAzideat1mgmL
MyBiosource
0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405
MUC6 (Mucin 6 / Gastric Mucin) Mouse Monoclonal Antibody
MBS439748-5x01mgWithBSAAzideat02mgmL
MyBiosource
5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725
MUC6 (Mucin 6 / Gastric Mucin) Mouse Monoclonal Antibody
MBS439748-5x01mgWithoutBSAAzideat1mgmL
MyBiosource
5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725
MUC6 (Mucin 6 / Gastric Mucin) Mouse Monoclonal Antibody
MBS439027-002mgWithBSAAzideat02mgmL
MyBiosource
0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230
MUC6 (Mucin 6 / Gastric Mucin) Mouse Monoclonal Antibody
MBS439027-01mgWithBSAAzideat02mgmL
MyBiosource
0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405
MUC6 (Mucin 6 / Gastric Mucin) Mouse Monoclonal Antibody
MBS439027-01mgWithoutBSAAzideat1mgmL
MyBiosource
0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405
MUC6 (Mucin 6 / Gastric Mucin) Mouse Monoclonal Antibody
MBS439027-5x01mgWithBSAAzideat02mgmL
MyBiosource
5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725
MUC6 (Mucin 6 / Gastric Mucin) Mouse Monoclonal Antibody
MBS439027-5x01mgWithoutBSAAzideat1mgmL
MyBiosource
5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725
MUC6 (Mucin 6 / Gastric Mucin) Mouse Monoclonal Antibody
MBS439358-002mgWithBSAAzideat02mgmL
MyBiosource
0.02mg(WithBSA&Azideat0.2mg/mL)
EUR 230
MUC6 (Mucin 6 / Gastric Mucin) Mouse Monoclonal Antibody
MBS439358-01mgWithBSAAzideat02mgmL
MyBiosource
0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 405
MUC6 (Mucin 6 / Gastric Mucin) Mouse Monoclonal Antibody
MBS439358-01mgWithoutBSAAzideat1mgmL
MyBiosource
0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 405
MUC6 (Mucin 6 / Gastric Mucin) Mouse Monoclonal Antibody
MBS439358-5x01mgWithBSAAzideat02mgmL
MyBiosource
5x0.1mg(WithBSA&Azideat0.2mg/mL)
EUR 1725
MUC6 (Mucin 6 / Gastric Mucin) Mouse Monoclonal Antibody
MBS439358-5x01mgWithoutBSAAzideat1mgmL
MyBiosource
5x0.1mg(WithoutBSA&Azideat1mg/mL)
EUR 1725
MUC5AC (Mucin 5AC / Gastric Mucin); Clone 45M1 (Concentrate)
RA0221-C.1
ScyTek Laboratories
0.1 ml
EUR 60.07
MUC5AC (Mucin 5AC / Gastric Mucin); Clone 45M1 (Concentrate)
RA0221-C.5
ScyTek Laboratories
0.5 ml
EUR 200.66
MUC5AC (Mucin 5AC / Gastric Mucin); Clone CLH2 (Concentrate)
RA0222-C.1
ScyTek Laboratories
0.1 ml
EUR 60.07
MUC5AC (Mucin 5AC / Gastric Mucin); Clone CLH2 (Concentrate)
RA0222-C.5
ScyTek Laboratories
0.5 ml
EUR 200.66
259 Patients with DCIS of the breast applying USC/Van Nuys prognostic index: a retrospective review with long term follow up.
BACKGROUND
The Van Nuys Prognostic Index (VNPI) is a simple score for predicting the risk of local recurrence (LR) in patients with Ductal Carcinoma In Situ (DCIS) conservatively treated. This score combines three independent predictors of Local Recurrence. The VNPI has recently been updated with the addition of age as a fourth parameter into the scoring system (University of Southern California/ VNPI).
METHODS
Our database consisted of 408 women with DCIS. Applying the USC/VNPI we reviewed retrospectively 259 patients who were treated with breast conserving surgery with or without radiotherapy (RT). Of these patients 63.5% had a low VNPI score, 32% intermediate and 4.5% a high score . In the low score group, the majority of the patients underwent Conservative Surgery (CS) without RT while in the intermediate group, almost half of the patients received RT. Eighty-three percent (83%) of the patients with high VNPI were treated with Conservative Surgery plus RT. Nodal assessment by Sentinel Lymph Node Biopsy was obtained in 32 patients since 2002.
RESULTS
Twenty-one Local Recurrences were observed (8%) with a mean follow up of 130 months: sixteen were invasive. No statistically significant differences in Disease Free Survival were reached in all groups of VNPI score between patients treated with Conservative Surgery or Conservative Surgery plus RT. However it was noted that the higher the VNPI score, the lower was the risk of local recurrence in the group treated additionally with RT, even though it was not statistically significant. Further analysis included those patients treated with Conservative Surgery alone and followed up. Disease-free survival (DFS) at 10 years was 94% with low VNPI and 83% in both intermediate and high score (P < 0.05). No significant differences were observed in the subgroups of VNPI.
The Local Relapse rate after Conservative Surgery alone, increased with tumor size, margin width, and pathology classification (P < 0,05), while age was not found to be a significant factor. Lesions with only mammographic appearances are associated with lower DFS but it did not reach significance (P = ns), while assumption of estrogenic hormones and familial history of breast cancer are significant factors associated with a higher risk of local recurrence. After multivariate analysis including seven clinical and pathological factors, the only significant predictors of local recurrence remained margin width of surgical excision, previous therapy with estrogens (contraceptives or Hormone Replacement Therapy) and the Van Nuys pathologic classification.
The overall survival breast cancer specific was 99% and no differences were observed between groups (P = ns). The comparison of patients treated with a total mastectomy and those conservatively treated showed a significantly better local relapse free survival rate obtained with mastectomy (98.2% vs. 89.7% at 10 years P = 0.02). However, the overall cause-specific survival did not prove any better outcome (98.7% in both groups). Of the 32 patients who underwent a Sentinel Lymph Node Biopsy, four were found to have micrometastases and all of them had a previous Directional Vacuum Assisted Biopsy.
CONCLUSIONS
Although in our series there is not a significant difference in LR rates by the parameter of age, the new USC/VNPI is still a simple and reliable scoring system for therapeutic management of DCIS. We did not find any statistically significant advantage in groups treated with the addition of RT. Obtaining wide surgical margins appears to be the strongest prognostic factor for local recurrence, regardless of other pathological factors or the addition of adjuvant radiation therapy. However, only prospective randomized studies can precisely predict the risk of LR of conservatively treated DCIS.
The clinical significance of Sentinel Lymph Nodes micrometastases Immuno –Histo –Chemistry -detected found in DCIS patients remains uncertain. However, we hypothesize that the anatomical disruption after preoperative biopsy procedures increases the likelihood of epithelial cell displacement and the frequency of IHC-positive Sentinel Lymph Nodes, both of which are directly proportional to the degree of manipulation.
Tissue biodistribution of intravenously administrated titanium dioxide nanoparticles revealed blood-brain barrier clearance and brain inflammation in rat.
BACKGROUND
Notwithstanding increasing knowledge of titanium dioxide nanoparticles (TiO2 NPs) passing through biological barriers, their biodistribution to the central nervous system (CNS) and potential effects on blood-brain barrier (BBB) physiology remain poorly characterized.
METHODS
Here, we report time-related responses from single-dose intravenous (IV) administration of 1 mg/kg TiO2 NPs to rats, with particular emphasis on titanium (Ti) quantification in the brain. Ti content in tissues was analyzed using inductively coupled plasma mass spectrometry. Integrity and functionality of the BBB as well as brain inflammation were characterized using a panel of methods including RT-PCR, immuno –histo chemistry and transporter activity evaluation.
RESULTS
Biokinetic analysis revealed Ti biopersistence in liver, lungs and spleen up to one year after TiO2 NPs administration. A significant increase of Ti in the brain was observed at early end points followed by a subsequent decrease. In-depth analysis of Ti in the total brain demonstrated quantitative Ti uptake and clearance by brain microvasculature endothelial cells (BECs) with minimal translocation in the brain parenchyma. The presence of Ti in the BECs did not affect BBB integrity, despite rapid reversible modulation of breast cancer resistance protein activity.
Ti biopersistence in organs such as liver was associated with significant increases of tight junction proteins (claudin-5 and occludin), interleukin 1β (IL-1β), chemokine ligand 1 (CXCL1) and γ inducible protein-10 (IP-10/CXCL10) in BECs and also increased levels of IL-1β in brain parenchyma despite lack of evidence of Ti in the brain. These findings mentioned suggest potential effect of Ti present at a distance from the brain possibly via mediators transported by blood. Exposure of an in vitro BBB model to sera from TiO2 NPs-treated animals confirmed the tightness of the BBB and inflammatory responses.
CONCLUSIONS
Overall, these findings suggest the clearance of TiO2 NPs at the BBB with persistent brain inflammation and underscore the role of Ti biopersistence in organs that can exert indirect effects on the CNS dependent on circulating factors.
Recombinant Nestin (NES)
RPA500Ra01
Cloud-Clone
10ug
EUR 183
Recombinant Nestin (NES)
4-RPA500Ra01
Cloud-Clone
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10ug
50ug
100 ug
200 ug
500 ug
1 mg
5 mg
Description: Recombinant Rat Nestin expressed in: E.coli
ELISA Kit for Nestin (NES)
SEA500Hu
Cloud-Clone
96Т
EUR 630
ELISA Kit for Nestin (NES)
SEA500Mu
Cloud-Clone
96Т
EUR 648
ELISA Kit for Nestin (NES)
SEA500Ra
Cloud-Clone
96Т
EUR 850
Human Nestin (NES) ELISA Kit
SEA500Hu-10x96wellstestplate
Cloud-Clone
10x96-wells test plate
EUR 5128.02
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Nestin (NES) in tissue homogenates, cell lysates and other biological fluids.
Human Nestin (NES) ELISA Kit
SEA500Hu-1x48wellstestplate
Cloud-Clone
1x48-wells test plate
EUR 527.48
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Nestin (NES) in tissue homogenates, cell lysates and other biological fluids.
Human Nestin (NES) ELISA Kit
SEA500Hu-1x96wellstestplate
Cloud-Clone
1x96-wells test plate
EUR 702.12
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Nestin (NES) in tissue homogenates, cell lysates and other biological fluids.
Human Nestin (NES) ELISA Kit
SEA500Hu-5x96wellstestplate
Cloud-Clone
5x96-wells test plate
EUR 2799.54
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Human Nestin (NES) in tissue homogenates, cell lysates and other biological fluids.
Human Nestin (NES) ELISA Kit
4-SEA500Hu
Cloud-Clone
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1 plate of 96 wells
5 plates of 96 wells
10 plates of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Human Nestin (NES) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.
Mouse Nestin (NES) ELISA Kit
SEA500Mu-10x96wellstestplate
Cloud-Clone
10x96-wells test plate
EUR 5269.39
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Nestin (NES) in tissue homogenates, cell lysates and other biological fluids.
Mouse Nestin (NES) ELISA Kit
SEA500Mu-1x48wellstestplate
Cloud-Clone
1x48-wells test plate
EUR 539.12
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Nestin (NES) in tissue homogenates, cell lysates and other biological fluids.
Mouse Nestin (NES) ELISA Kit
SEA500Mu-1x96wellstestplate
Cloud-Clone
1x96-wells test plate
EUR 718.75
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Nestin (NES) in tissue homogenates, cell lysates and other biological fluids.
Mouse Nestin (NES) ELISA Kit
SEA500Mu-5x96wellstestplate
Cloud-Clone
5x96-wells test plate
EUR 2874.38
Description: This is Double-antibody Sandwich Enzyme-linked immunosorbent assay for detection of Mouse Nestin (NES) in tissue homogenates, cell lysates and other biological fluids.
Mouse Nestin (NES) ELISA Kit
4-SEA500Mu
Cloud-Clone
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1 plate of 96 wells
5 plates of 96 wells
10 plates of 96 wells
Description: Enzyme-linked immunosorbent assay based on the Double-antibody Sandwich method for detection of Mouse Nestin (NES) in samples from tissue homogenates, cell lysates and other biological fluids with no significant corss-reactivity with analogues from other species.
Monoclonal Antibody to Nestin (NES)
MAA500Hu21
Cloud-Clone
100ul
EUR 235
Monoclonal Antibody to Nestin (NES)
MAA500Hu22
Cloud-Clone
100ul
EUR 235
Monoclonal Antibody to Nestin (NES)
MAA500Hu24
Cloud-Clone
100ul
EUR 243
Polyclonal Antibody to Nestin (NES)
PAA500Hu01
Cloud-Clone
100ul
EUR 221
Polyclonal Antibody to Nestin (NES)
PAA500Mu01
Cloud-Clone
100ul
EUR 227
Polyclonal Antibody to Nestin (NES)
PAA500Ra01
Cloud-Clone
100ul
EUR 239
Monoclonal Nestin Antibody (clone 10C2), Clone: 10C2
AMM02186G
Leading Biology
0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human Nestin (clone 10C2). The antibodies are raised in Mouse and are from clone 10C2. This antibody is applicable in WB and IHC-P, IHC-Fr
Monoclonal Nestin Antibody (clone 10C2), Clone: 10C2
AMM02263G
Leading Biology
0.05mg
EUR 580.8
Description: A Monoclonal antibody against Human Nestin (clone 10C2). The antibodies are raised in Mouse and are from clone 10C2. This antibody is applicable in WB and IHC-P, ICC, IHC-Fr
Monoclonal Nestin Antibody, Clone: 4D11
AMM02595G
Leading Biology
0.1ml
EUR 580.8
Description: A Monoclonal antibody against Human Nestin. The antibodies are raised in Mouse and are from clone 4D11. This antibody is applicable in WB and IF
Nestin (NES) Polyclonal Antibody (Rat)
4-PAA500Ra01
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Rat Nestin (NES)
Monoclonal Nestin Antibody (clone 2C1.3A11), Clone: 2C1.3A11
AMM01780G
Leading Biology
0.05ml
EUR 580.8
Description: A Monoclonal antibody against Human Nestin (clone 2C1.3A11). The antibodies are raised in Mouse and are from clone 2C1.3A11. This antibody is applicable in WB and IHC-P, ICC, IP, Flo
Nestin (NES) Polyclonal Antibody (Human)
4-PAA500Hu01
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Human Nestin (NES)
Nestin (NES) Polyclonal Antibody (Mouse)
4-PAA500Mu01
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES)
Nestin (NES) Polyclonal Antibody (Rat), PE
4-PAA500Ra01-PE
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Rat Nestin (NES). This antibody is labeled with PE.
Nestin (NES) Polyclonal Antibody (Rat), APC
4-PAA500Ra01-APC
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Rat Nestin (NES). This antibody is labeled with APC.
Nestin (NES) Polyclonal Antibody (Rat), Cy3
4-PAA500Ra01-Cy3
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Rat Nestin (NES). This antibody is labeled with Cy3.
Nestin (NES) Polyclonal Antibody (Rat), HRP
4-PAA500Ra01-HRP
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Rat Nestin (NES). This antibody is labeled with HRP.
Nestin (NES) Polyclonal Antibody (Human), PE
4-PAA500Hu01-PE
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Human Nestin (NES). This antibody is labeled with PE.
Nestin (NES) Polyclonal Antibody (Mouse), PE
4-PAA500Mu01-PE
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES). This antibody is labeled with PE.
Nestin (NES) Polyclonal Antibody (Rat), FITC
4-PAA500Ra01-FITC
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Rat Nestin (NES). This antibody is labeled with FITC.
Nestin (NES) Monoclonal Antibody (Human, Rat)
4-MAA500Hu21
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES)
Nestin (NES) Monoclonal Antibody (Human, Rat)
4-MAA500Hu22
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES)
Nestin (NES) Polyclonal Antibody (Human), APC
4-PAA500Hu01-APC
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Human Nestin (NES). This antibody is labeled with APC.
Nestin (NES) Polyclonal Antibody (Human), Cy3
4-PAA500Hu01-Cy3
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Human Nestin (NES). This antibody is labeled with Cy3.
Nestin (NES) Polyclonal Antibody (Human), HRP
4-PAA500Hu01-HRP
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Human Nestin (NES). This antibody is labeled with HRP.
Nestin (NES) Polyclonal Antibody (Mouse), APC
4-PAA500Mu01-APC
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES). This antibody is labeled with APC.
Nestin (NES) Polyclonal Antibody (Mouse), Cy3
4-PAA500Mu01-Cy3
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES). This antibody is labeled with Cy3.
Nestin (NES) Polyclonal Antibody (Mouse), HRP
4-PAA500Mu01-HRP
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES). This antibody is labeled with HRP.
Nestin (NES) Polyclonal Antibody (Human), FITC
4-PAA500Hu01-FITC
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Human Nestin (NES). This antibody is labeled with FITC.
Nestin (NES) Polyclonal Antibody (Mouse), FITC
4-PAA500Mu01-FITC
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES). This antibody is labeled with FITC.
Nestin (NES) Polyclonal Antibody (Rat), Biotinylated
4-PAA500Ra01-Biotin
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Rat Nestin (NES). This antibody is labeled with Biotin.
Nestin (NES) Monoclonal Antibody (Human, Rat), PE
4-MAA500Hu21-PE
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with PE.
Nestin (NES) Monoclonal Antibody (Human, Rat), PE
4-MAA500Hu22-PE
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with PE.
Nestin (NES) Monoclonal Antibody (Human, Rat), APC
4-MAA500Hu21-APC
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with APC.
Nestin (NES) Monoclonal Antibody (Human, Rat), Cy3
4-MAA500Hu21-Cy3
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with Cy3.
Nestin (NES) Monoclonal Antibody (Human, Rat), HRP
4-MAA500Hu21-HRP
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with HRP.
Nestin (NES) Monoclonal Antibody (Human, Rat), APC
4-MAA500Hu22-APC
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with APC.
Nestin (NES) Monoclonal Antibody (Human, Rat), Cy3
4-MAA500Hu22-Cy3
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with Cy3.
Nestin (NES) Monoclonal Antibody (Human, Rat), HRP
4-MAA500Hu22-HRP
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with HRP.
Nestin (NES) Polyclonal Antibody (Rat), APC-Cy7
4-PAA500Ra01-APC-Cy7
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Rat Nestin (NES). This antibody is labeled with APC-Cy7.
Nestin (NES) Polyclonal Antibody (Human), Biotinylated
4-PAA500Hu01-Biotin
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Human Nestin (NES). This antibody is labeled with Biotin.
Nestin (NES) Polyclonal Antibody (Mouse), Biotinylated
4-PAA500Mu01-Biotin
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES). This antibody is labeled with Biotin.
Nestin (NES) Monoclonal Antibody (Human, Rat), FITC
4-MAA500Hu21-FITC
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with FITC.
Nestin (NES) Monoclonal Antibody (Human, Rat), FITC
4-MAA500Hu22-FITC
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with FITC.
Nestin (NES) Polyclonal Antibody (Human), APC-Cy7
4-PAA500Hu01-APC-Cy7
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Human Nestin (NES). This antibody is labeled with APC-Cy7.
Nestin (NES) Polyclonal Antibody (Mouse), APC-Cy7
4-PAA500Mu01-APC-Cy7
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Rabbit polyclonal antibody against Mouse Nestin (NES). This antibody is labeled with APC-Cy7.
Nestin (NES) Mouse Monoclonal Antibody [Clone:1B4]
E45M18854
EnoGene
100 ug
EUR 595
Nestin (NES) Mouse Monoclonal Antibody [Clone 1B4]
E45M18854V-2
EnoGene
50 ul
EUR 195
Nestin (NES) Mouse Monoclonal Antibody [Clone:3B12]
E45M18831
EnoGene
100 ug
EUR 595
Nestin (NES) Mouse Monoclonal Antibody [Clone 3B12]
E45M18831V-2
EnoGene
50 ul
EUR 195
Nestin (NES) Monoclonal Antibody (Human, Rat), Biotinylated
4-MAA500Hu21-Biotin
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with Biotin.
Nestin (NES) Monoclonal Antibody (Human, Rat), Biotinylated
4-MAA500Hu22-Biotin
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with Biotin.
Nestin (NES) Monoclonal Antibody (Human, Rat), APC-Cy7
4-MAA500Hu21-APC-Cy7
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with APC-Cy7.
Nestin (NES) Monoclonal Antibody (Human, Rat), APC-Cy7
4-MAA500Hu22-APC-Cy7
Cloud-Clone
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20ul
100ul
200ul
1ml
10ml
Description: A Mouse monoclonal antibody against Human, Rat Nestin (NES). This antibody is labeled with APC-Cy7.
Nestin (NES) Mouse Monoclonal Antibody [Clone UMLBI267]
E45M22000V-2
EnoGene
50 ul
EUR 255
Nestin (NES) Mouse Monoclonal Antibody [Clone ID: UMLBI267]
E45M22000
EnoGene
100 ug
EUR 595
Mouse Anti-Human Nestin monoclonal antibody, clone JID749
CABT-L3001
Creative Diagnostics
100 µl, 500 µl
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Description: Mouse
Mouse Anti-Human Nestin monoclonal antibody, clone JID749
CABT-L3001-100uL500uL
Creative Diagnostics
100 uL, 500 uL
EUR 602.4
Rabbit Anti-Human Nestin monoclonal antibody, clone TO17-38
DCABH-6339
Creative Diagnostics
100 ul
EUR 575.4
Description: Rabbit
Nestin
AP85721
SAB
1mg
EUR 2640
Nestin
AP85527
SAB
1mg
EUR 2640
Nestin
AP86099
SAB
1mg
EUR 2640
Nestin
E8ET1611-21
EnoGene
100ul
EUR 275
Description: Available in various conjugation types.
Nestin
E8R1510-19
EnoGene
100ul
EUR 275
Description: Available in various conjugation types.
Nestin
E8R1510-20
EnoGene
100ul
EUR 275
Description: Available in various conjugation types.
Nestin
MBS373060-01mLConcentrate
MyBiosource
0.1mL(Concentrate)
EUR 310
Nestin
MBS373060-05mLConcentrate
MyBiosource
0.5mL(Concentrate)
EUR 655
Nestin
MBS373060-1mLConcentrate
MyBiosource
1mL(Concentrate)
EUR 910
Nestin
MBS344072-INQUIRE
MyBiosource
INQUIRE
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Nestin
MBS8534031-01mLAF405L
MyBiosource
0.1mL(AF405L)
EUR 565
Nestin
MBS8534031-01mLAF405S
MyBiosource
0.1mL(AF405S)
EUR 565
Nestin
MBS8534031-01mLAF610
MyBiosource
0.1mL(AF610)
EUR 565
Nestin
MBS8534031-01mLAF635
MyBiosource
0.1mL(AF635)
EUR 565
Nestin
MBS8534810-01mLAF405L
MyBiosource
0.1mL(AF405L)
EUR 565
Nestin
MBS8534810-01mLAF405S
MyBiosource
0.1mL(AF405S)
EUR 565
Nestin
MBS8534810-01mLAF610
MyBiosource
0.1mL(AF610)
EUR 565