[Desmoplastic tumors with multiple differentiation. A new entity. Six cases].

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June 28, 2021 0 Comments

[Desmoplastic tumors with multiple differentiation. A new entity. Six cases].

Desmoplastic tumours with divergent differentiation are principally located in the abdomen and develop locally or regionally. They occur in adolescents or young adults and are characterized at histology by a proliferation of undifferentiated small cells surrounded by a dense stroma. Only immunohistochemistry provides the diagnosis. Since their chemosensitivity is rare and often partial the outcome is usually lethal. Six new cases of this recently described entity are presented here. The authors are in favour of a multidisciplinary and aggressive management, combining intensive polychemotherapy, extensive surgical exerisis and total abdominal radiotherapy.
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Comparison of the Effect of Adipocyte-derived Stem Cells and Curcumin Nanoliposomes with Phenytoin on Open Cutaneous Wound Healing in Rats

Background: Reducing the healing time of wounds can decrease the patient’s immobility time and their medical costs,leading a faster return of the patients to daily work.
Objective: To compare the effect of adipose-derived stem cells and curcumin-containing liposomal nanoparticles with phenytoin on wound healing.
Method: After anesthesia of the rats, open skin ulcers were made by a bistoury blade.Subsequently,stem cells were re-moved from the adipose tissue of the upper border of the epididymis. Then,the originality of stem cells was confirmed by the flow cytometry. The fusion method was used to prepare the liposome;and also nanoliposomal particles were confirmed by using the DLS microscope.The percentage of recovery and the cell count was measured with IMAGEJ.The expression of genes was assessed by PCR. The number of fibro blasts was counted by immuno histo chemistry techniques.The amount of collagen was determined by Tri-chromosome staining and the number of capillaries was enumerated byH & E staining.
 
Results: The expression of TGF-β1 gene, vascular number, wound healing rate and the number of fibro blasts increased significantly in adipose tissue-derived stem cells and curcumin nanoliposome groups(p<0.05);the wound surface was also decreased significantly(p<0.05).
Conclusion: Based on the results of our research, adipose tissue-derived stem cells and curcumin nanoliposomescan heal wounds efficiently.

Linking Helicobacter pylori with gallbladder and biliary tract cancer in Moroccan population using clinical and pathological profiles.

It is of interest to assess the clinical and pathological aspects of Gallbladder and biliary tract carcinomas confirmed by histological data. It is also of further interest to evaluate the link between Helicobacter pylori and biliary tract cancers. Eighty-nine (89) cases (mean age 60±12 years) of Gallbladder and biliary tract cancer confirmed by histological data were enrolled for the study at the Department of Pathology in Mohammed VI University Hospital, in Morocco. The data such as age, sex, clinical and histo pathological features were collected.

 

Bile duct specimens were investigated for H. pylori using Giemsa and immuno histo chemistry staining. Results show that bile duct stones were found in 53.9% of cases. It is known using histological data that adeno carcinoma is common accounting for 70 % of all bile duct tumors. Moreover, Helicobacter pylori was detected in 54% of cases linking with the presence of bile duct stones characterized by the histological subtype, the macroscopic classification and lymph node’s presence (p<0.001). Thus, data collected suggest the potential association of Helicobacter pylori with gallbladder cancer possibly through the formation of bile duct stones.

[Sentinel node detection applied to breast cancer: 2007 update].

The technique of detection and resection of the sentinel lymph node applied to early breast cancer management aims to spare the patient with a low risk of lymph node involvement an unnecessary axillary lymphadenectomy. This innovating technique lies on the double hypothesis of an accuracy to predict non sentinel lymph node status and to induce a lower morbidity when compared with axillary lymphadenectomy.
This multidisciplinary technique depends on surgeons, nuclear physicians and pathologists. In practice sentinel lymph nodes are detected thanks to two types of tracers, the Blue and the colloids marked with technetium, harvested by the surgeon guided by the blue lymphatic channel and the use of a gamma probe detection, analyzed by the pathologist according to a particular procedure with the concept of serial slices, and possibly immuno histo chemistry. The objectives of this review are to specify the state of knowledge concerning the different steps: detection, surgical resection and the pathological analysis of the sentinels lymph nodes and to focus on validated and controversial indications, and on the main ongoing trials.

Investigating the levels of soluble extracellular domain of HER2 protein in the sera of meningioma patients.

OBJECTIVE
Meningiomas are the most frequently diagnosed primary central nervous system (CNS) neoplasms. Considering slightly higher incidence of meningiomas in breast cancer patients and breast cancer in meningioma patients, it can be assumed that both tumors share similar risk factors.
HER2 gene amplification and/or over-expression have been found in several human cancers, but it has been most widely studied in breast carcinomas. Bearing in mind the association of breast cancer and meningioma, the present study aimed to investigate the levels of the soluble extracellular domain of HER2 protein in meningioma cases and control group. Besides, in the present research, its associations with pathological features and prognostic indicators of meningioma were examined.
METHODS
In the present study, 68 meningioma patients along with 20 healthy age-sex matched individuals, as controls, were selected. Levels of HER2 in the sera were measured by a quantitative enzyme-linked immunosorbent assay (ELISA).
RESULTS
The observations showed that HER2 serum levels in meningioma patients were significantly lower than normal controls. However, outlier quantities were mostly observed in the cases. Furthermore, in meningiomas with higher histological grade (grade II, III), statistically significant elevated serum levels of HER2 were observed compared to patients with low-grade meningiomas (grade I).

 

Immunohistochemistry Kit (OKRA00038)

OKRA00038 1 kit
EUR 966
Description: Description of target: ;Species reactivity: ;Application: ;Assay info: ;Sensitivity:

Immunohistochemistry Kit (OKRA00039)

OKRA00039 1 kit
EUR 966
Description: Description of target: ;Species reactivity: ;Application: ;Assay info: ;Sensitivity:

Immunohistochemistry Kit (OKRA00040)

OKRA00040 1 kit
EUR 966
Description: Description of target: ;Species reactivity: ;Application: ;Assay info: ;Sensitivity:

HiPer® Immunohistochemistry Teaching Kit

HTI023-5PR 1 unit
EUR 144.14
Description: HiPer® Immunohistochemistry Teaching Kit

Prediluted for Immunohistochemistry

RP-4003-04 7.0 ml
EUR 79.65

Tn, Prediluted for Immunohistochemistry

MM-1018-04 7.0 ml
EUR 120.05

Tg, Prediluted for Immunohistochemistry

MM-1021-04 7.0 ml
EUR 120.05

Tg, Prediluted for Immunohistochemistry

RP-4009-04 7.0 ml
EUR 79.65

K Prediluted for Immunohistochemistry

RP-4020-04 7.0 ml
EUR 79.65

EMA, Prediluted for Immunohistochemistry

MM-1001-04 7.0 ml
EUR 120.05

hCG, Prediluted for Immunohistochemistry

MM-1005-04 7.0 ml
EUR 120.05

ESA, Prediluted for Immunohistochemistry

MM-1014-04 7.0 ml
EUR 120.05

p53, Prediluted for Immunohistochemistry

MM-1015-04 7.0 ml
EUR 120.05

STn, Prediluted for Immunohistochemistry

MM-1019-04 7.0 ml
EUR 120.05

TSH, Prediluted for Immunohistochemistry

MM-1020-04 7.0 ml
EUR 120.05

CTP, Prediluted for Immunohistochemistry

RP-4004-04 7.0 ml
EUR 79.65

CEA, Prediluted for Immunohistochemistry

RP-4005-04 7.0 ml
EUR 79.65

PSA, Prediluted for Immunohistochemistry

RP-4010-04 7.0 ml
EUR 79.65

MBP, Prediluted for Immunohistochemistry

RP-4015-04 7.0 ml
EUR 79.65

AFP, Prediluted for Immunohistochemistry

RP-4017-04 7.0 ml
EUR 79.65

AαSM, Prediluted for Immunohistochemistry

MM-1004-04 7.0 ml
EUR 120.05

PCNA, Prediluted for Immunohistochemistry

MM-1016-04 7.0 ml
EUR 120.05

MUC2, Prediluted for Immunohistochemistry

RP-4013-04 7.0 ml
EUR 79.65

S100, Prediluted for Immunohistochemistry

RP-4014-04 7.0 ml
EUR 79.65

GFAP, Prediluted for Immunohistochemistry

RP-4016-04 7.0 ml
EUR 79.65

A1AT, Prediluted for Immunohistochemistry

RP-4019-04 7.0 ml
EUR 79.65

CK 19, Prediluted for Immunohistochemistry

MM-1002-04 7.0 ml
EUR 120.05

CK 18, Prediluted for Immunohistochemistry

MM-1009-04 7.0 ml
EUR 120.05

HBcAg, Prediluted for Immunohistochemistry

RP-4006-04 7.0 ml
EUR 79.65

CK AE1, Prediluted for Immunohistochemistry

MM-1010-04 7.0 ml
EUR 120.05

CK AE3, Prediluted for Immunohistochemistry

MM-1011-04 7.0 ml
EUR 120.05

S 100, Prediluted for Immunohistochemistry

MM-1017-04 7.0 ml
EUR 120.05

Lambda, Prediluted for Immunohistochemistry

RP-4021-04 7.0 ml
EUR 79.65

Desmin, Prediluted for Immunohistochemistry

RP-4023-04 7.0 ml
EUR 79.65

CK 8+18, Prediluted for Immunohistochemistry

MM-1007-04 7.0 ml
EUR 120.05

CK 10+13, Prediluted for Immunohistochemistry

MM-1008-04 7.0 ml
EUR 120.05

Insulin Prediluted for Immunohistochemistry

RP-4012-04 7.0 ml
EUR 79.65

PR Immunohistochemistry control tissue array

PM2-PR each
EUR 78
Description: PR Immunohistochemistry control tissue array, including TNM and pathology grade of breast cancer, 11 cases/11 cores

Ferritin, Prediluted for Immunohistochemistry

RP-4001-04 7.0 ml
EUR 79.65

Vimentin, Prediluted for Immunohistochemistry

RP-4002-04 7.0 ml
EUR 79.65

Lysozyme, Prediluted for Immunohistochemistry

RP-4018-04 7.0 ml
EUR 79.65

Calcitonin, Prediluted for Immunohistochemistry

RP-4007-04 7.0 ml
EUR 79.65

Ubiquintin, Prediluted for Immunohistochemistry

RP-4011-04 7.0 ml
EUR 79.65

CK cocktail. Prediluted for Immunohistochemistry

MM-1012-04 7.0 ml
EUR 191.1

Transferrin, Prediluted for Immunohistochemistry

RP-4022-04 7.0 ml
EUR 79.65

Sialosyl Le (a), Prediluted for Immunohistochemistry

MM-1003-04 7.0 ml
EUR 120.05

Synaptophysin, Prediluted for Immunohistochemistry

RP-4008-04 7.0 ml
EUR 79.65

Normal Rabbit Control Serum (for immunohistochemistry)

NRS-IHC 500 μl
EUR 267.84

GWB-55335F-3ML - DAB Immunohistochemistry Substrate

GWB-55335F-3ML 3ml
EUR 143

Myeloperoxidase (MPO), Prediluted for Immunohistochemistry

RP-4025-04 7.0 ml
EUR 79.65

Luteinizing Hormone (LH), Prediluted for Immunohistochemistry

RP-4024-04 7.0 ml
EUR 79.65

Cytokeratin AE1 and AE3, Prediluted for Immunohistochemistry

MM-1022-04 7.0 ml
EUR 136.15

Breast cancer with ER Immunohistochemistry control tissue array

PM2a-ER each
EUR 78
Description: Breast cancer with ER Immunohistochemistry control tissue array, including pathology grade, TNM, clinical stage and IHC results of ER/PR/Her-2/Ki67, 10 cases/10 cores, replacing PM2-ER

OOMB00003-10ML - Blocking Buffer for Immunocytochemistry and Immunohistochemistry

OOMB00003-10ML 10mL
EUR 79

OOMB00006-100ML - 10X Antigen Retrieval Solution pH 6.0 for Immunohistochemistry

OOMB00006-100ML 100mL
EUR 79

OOMB00007-100ML - 10X Antigen Retrieval Solution pH 9.0 for Immunohistochemistry

OOMB00007-100ML 100mL
EUR 79

OOMB00004-10ML - Permeabilization Buffer for Immunocytochemistry and Immunohistochemistry

OOMB00004-10ML 10mL
EUR 79

Super PlusTMHigh Sensitive and Rapid Immunohistochemical Kit (pH9.0)

E-IR-R220-10mL 10mL
EUR 325

Super PlusTMHigh Sensitive and Rapid Immunohistochemical Kit (pH9.0)

E-IR-R220-3mL 3mL
EUR 125

Super PlusTMHigh Sensitive and Rapid Immunohistochemical Kit (pH9.0)

E-IR-R220-each each Ask for price

Super PlusTMHigh Sensitive and Rapid Immunohistochemical Kit (pH6.0)

E-IR-R221-10mL 10mL
EUR 325

Super PlusTMHigh Sensitive and Rapid Immunohistochemical Kit (pH6.0)

E-IR-R221-3mL 3mL
EUR 125

Super PlusTMHigh Sensitive and Rapid Immunohistochemical Kit (pH6.0)

E-IR-R221-each each Ask for price

ImmunoHistozyme

AR-6547-01 15 ml
EUR 47.75

ImmunoHistozyme

AR-6547-02 100 ml
EUR 95.55

ImmunoHistoMount™

AR-6503-01 30 ml
EUR 60.05

ImmunoHistoMount™

AR-6503-02 100 ml
EUR 111.65

ImmunoHistoMount™

AR-6503-03 250 ml
EUR 203.35

ImmunoHistoMount™

AR-6503-05 1000 ml
EUR 556.5

BrdU IHC Kit

KT-077 50 slides
EUR 652

Apoptosis Inhibitor 5 IHC Antibody

IW-PA1009 -
EUR 285

IHC-Tek DAB Peroxidase Substrate Kit - 120 ml

IW-1600 -
EUR 125

IHC-Tek AEC Peroxidase Substrate Kit - 120 ml

IW-1601 -
EUR 125

CD3 IHC Antibody

IW-MA1015 -
EUR 285

p53 IHC Antibody

IW-MA1078 -
EUR 285

Tau IHC Antibody

IW-MA1093 -
EUR 285

MBP IHC Antibody

IW-PA1050 -
EUR 285

NSE IHC Antibody

IW-PA1061 -
EUR 285

GFAP IHC Antibody

IW-MA1045 -
EUR 285

PCNA IHC Antibody

IW-MA1083 -
EUR 285

ANG2 IHC Antibody

IW-PA1005 -
EUR 285

CD22 IHC Antibody

IW-PA1018 -
EUR 285

CD44 IHC Antibody

IW-PA1021 -
EUR 285

COX1 IHC Antibody

IW-PA1027 -
EUR 285

PP2A IHC Antibody

IW-PA1068 -
EUR 285

RAGE IHC Antibody

IW-PA1069 -
EUR 285

VEGF IHC Antibody

IW-PA1080 -
EUR 285

MMP2 IHC Antibody

IW-PA1122 -
EUR 285

COX2 IHC Antibody

IW-PA1211 -
EUR 285

FGF8 IHC Antibody

IW-PA1216 -
EUR 285

NF200 IHC Antibody

IW-MA1071 -
EUR 285

CD40L IHC Antibody

IW-PA1020 -
EUR 285

HSP40 IHC Antibody

IW-PA1043 -
EUR 285

HSP60 IHC Antibody

IW-PA1106 -
EUR 285

MMP16 IHC Antibody

IW-PA1123 -
EUR 285

OPCML IHC Antibody

IW-PA1131 -
EUR 285

TNFR2 IHC Antibody

IW-PA1243 -
EUR 285

APAF1 IHC Antibody

IW-PA1249 -
EUR 285

Desmin IHC Antibody

IW-MA1036 -
EUR 285

IFITM1 IHC Antibody

IW-PA1112 -
EUR 285

Elastin IHC Antibody

IW-MA1038 -
EUR 285

Insulin IHC Antibody

IW-MA1052 -
EUR 285

TNFaIP1 IHC Antibody

IW-PA1305 -
EUR 285

Glucagon IHC Antibody

IW-MA1047 -
EUR 285

Vimentin IHC Antibody

IW-MA1102 -
EUR 285

Calretinin IHC Antibody

IW-PA1015 -
EUR 285

Fibronectin IHC Antibody

IW-MA1116 -
EUR 285

Bcl-2 IHC Antibody

IW-MA1004 -
EUR 285

ABI-1 IHC Antibody

IW-PA1001 -
EUR 285

FAS-L IHC Antibody

IW-PA1101 -
EUR 285

SHP-2 IHC Antibody

IW-PA1114 -
EUR 285

Lamin B1 IHC Antibody

IW-PA1048 -
EUR 285

CD95/PAS IHC Antibody

IW-PA1119 -
EUR 285

TFPI-2 IHC Antibody

IW-PA1248 -
EUR 285

PKC alpha IHC Antibody

IW-PA1065 -
EUR 285

Annexin A1 IHC Antibody

IW-PA1006 -
EUR 285

alpha-SMA IHC Antibody

IW-MA1106 -
EUR 285

Connexin 43 IHC Antibody

IW-PA1026 -
EUR 285

TNF-alpha IHC Antibody

IW-PA1079 -
EUR 285

CBFA1/RUNX2 IHC Antibody

IW-PA1224 -
EUR 285

beta-Actin IHC Antibody

IW-MA1115 -
EUR 285

Cytochrome C IHC Antibody

IW-PA1118 -
EUR 285

pan Cytokeratin IHC Antibody

IW-MA1081 -
EUR 285

alpha-Tubulin IHC Antibody

IW-MA1107 -
EUR 285

Orexin Receptor IHC Antibody

IW-PA1100 -
EUR 285

Neurotrophin-3 IHC Antibody

IW-PA1062 -
EUR 285

MPO (Myeloperoxidase) IHC Antibody

IW-PA1054 -
EUR 285

IHC-Tek Epitope Retrieval Solution, Ready To Use, 500 ml IHC World: IW-1100

IW-1100 -
EUR 125

AKT 1/2 IHC Antibody

IW-PA1301 -
EUR 285

MAPK 1/3 IHC Antibody

IW-PA1049 -
EUR 285

Lamin A/C IHC Antibody

IW-PA1103 -
EUR 285

HIF-1 alpha IHC Antibody

IW-PA1041 -
EUR 285

CD54 (ICAM-1) IHC Antibody

IW-PA1110 -
EUR 285

HIF-2 alpha IHC Antibody

IW-PA1129 -
EUR 285

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